HIV感染者/AIDS病人CD_4^+T淋巴细胞与HIV病毒载量关联性分析

The correlation between CD_4^+T cell and HIV viral load in HIV infection / AIDS

目的:研究HIV感染者/AIDS病人CD4+T淋巴细胞与HIV病毒载量之间的相互关系。方法:使用NASBA方法(Easy Q)和流式细胞仪绝对计数法检测30名HIV感染者/AIDS病人的HIV病毒载量和CD4+T淋巴细胞数。结果:经过对115对有效数据进行双变量相关分析,结果显示:HIV病毒载量与CD4+T淋巴细胞数二者呈显著性负相关关系(r=-0.184 P=0.049)。结论:研究结果为观察和了解HIV感染者/AIDS病人感染状况或病程发展提供更科学的依据。

Objective： To determine the relationship between CD4^＋ cell count and HIV （Human Immunodeficiency Virus） viral load in HIV infection ＆ AIDS （Acquired Imrnunodeficiency Syndrome） cases. Methods：The HIV viral load and CD4^＋ count were measured using NASBA and FACS methods respectively. Thirty HIV infected individuals and AIDS patients were interviewed for clinical syndromes and tested for viral load and CD4^＋ count. Results： 115 pair of effective data were analyzed by bivariate correlation analysis which showed a negative correlation between CD4＋ cell count and HIV viral load （ r = - 0. 184, P = 0. 049）. Conclusions ：The research results provided more credible evidences for observing and understanding infection situation and disease development of HIV positive and AIDS cases.