105例早产儿早期补充维生素D对IL-2和免疫球蛋白的影响

Effect of early vitamin D supplementation on IL-2 and immunoglobulin in 105 premature infants

目的:探讨早期补充维生素D对早产儿免疫功能的影响。方法:选取北京大学深圳医院儿科新生儿病房105例早产儿为研究对象,分为大胎龄组(54例)和小胎龄组(51例),每组又随机分为对照组和研究组,对照组给予配方奶喂养,研究组给予配方奶+维生素D,从早产儿出生的第3日开始给予维生素D,400 U/d,连续1周。实验前后分别测定早产儿血清白细胞介素-2(IL-2)、25-(OH)D和Ig G、Ig A、Ig M水平,观察临床并发症发生情况。结果:早产儿普遍存在维生素D缺乏。给予维生素D治疗后,小胎龄组和大胎龄组血清25-(OH)D均值分别从(22.436±6.492)nmol/L和(26.654±7.864)nmol/L提高到(26.411±7.342)nmol/L和(31.768±7.88)nmol/L,差异均有统计学意义(P<0.05)。随着25-(OH)D水平的提高,IL-2水平明显提高,研究组与对照组比较差异有统计学意义(P<0.05);而Ig G、Ig A、Ig M水平治疗前后无明显变化(P>0.05)。结论:对于早产儿来说,早期补充维生素D可以提高其免疫力,但是早期补充维生素D对体液免疫的影响尚需研究。

Objective： To explore the effect of early vitamin D supplementation on immune function of premature infants. Methods： A total of 105 premature infants were selected from Neonatal Ward of Department of Pediatrics in this hospital as research objects,then they were divided into large gestational age group（ 54 infants） and small gestational age group（ 51 infants）,and the infants in each group were randomly divided into control group and study group,the infants in control group were fed with formula milk,while the infants in study group were fed with formula milk and vitamin D,vitamin D was given on the third day after birth,400 U per day for one week. The levels of interleukin- 2（ IL- 2）,25-（ OH） D and Ig G,Ig A,Ig M in serum before and after the experiment were detected respectively,the clinical complications were observed. Results： Vitamin D deficiency existed in premature infants widely. After treated with vitamin D,serum levels of 25-（ OH） D in large gestational age group and small gestational age group increased from（ 22. 436 ± 6. 492） nmol / L and（ 26. 654 ± 7. 864） nmol/L to（ 26. 411 ± 7. 342） nmol/L and（ 31. 768 ± 7. 88） nmol/L,respectively,there were statistically significant differences（ P〈0. 05）. IL- 2 level increased significantly with the increase of 25-（ OH） D level,there was statistically significant difference between study group and control group（ P〈0. 05）; there was no statistically significant difference in the levels of Ig G,Ig A and Ig M between before and after treatment（ P〉0. 05）. Conclusion： For premature infants,early vitamin D supplementation can improve the immunity,but its impact on humoral immunity needs to be studied.