椰子种皮油提取物对氧化损伤的保护作用

Protective effect of coconut endocarp oil extract on oxidative damage

以海南产椰子的种皮油提取物(CEOE)为研究对象,探讨了其对蛋白质羰基氧化的抑制作用、过氧化氢的清除能力、过氧化氢诱导的人血清蛋白氧化损伤和羟自由基引发的DNA损伤的保护作用。结果表明:CEOE可有效抑制过氧化氢引发的蛋白质羰基和氢过氧化物的增多;且2.5 mg/mL的CEOE对过氧化氢的清除率已达49.81%;同时该提取物还可以修复羟自由基诱导的DNA损伤;是一种值得开发的抗氧化剂资源。

Coconut（ Cocosnucifera L. ） endocarp oil extract （CEOE） obtained from the coconut grown up in Hain- an island were analyzed on its inhibiting effect on the oxidation of protein carbonyl, hydrogen peroxide scavenging ac- tivity, protective effect on hydrogen peroxide-induced oxidative damage to human serum albumin and hydroxyl radical -induced DNA damage. The results showed that CEOE could inhibit the increase of protein carbonyl and hydroperox- ides content induced by hydrogen peroxide effectively, and its scavenging activity on hydrogen peroxide was 49.81% at 2.5 mg/mL; meanwhile, CEOE was able to repair the DNA damage induced by hydroxyl radical, which suggested that CEOE might be a new worthy exploiting source of natural antioxidants.