2型糖尿病和糖耐量受损与同型半胱氨酸的关系研究被引量：3

下载PDF

导出

摘要目的:探讨高同型半胱氨酸与2型糖尿病及糖耐量受损的关系,探求2型糖尿病的干预和治疗方案。方法:选取64例初诊2型糖尿病患者(DM组),41例糖耐量受损患者(IGR组)与25例正常健康者作对照(NGT组),行口服葡萄糖耐量试验(OGTT),探讨同型半胱氨酸与血糖、胰岛素和HOMA-IR的关系。结果:2型糖尿病患者和糖耐量受损患者血HCY水平高于正常健康组,HCY与TC、TG、Hb Alc、HOMA-IR呈正相关;与HOMA-B呈负相关。结论:初诊2型糖尿病患者和糖耐量受损患者血清HCY水平高于正常对照组,高同型半胱氨酸血症是2型糖尿病患者产生胰岛素抵抗的相关因素。

作者张茜刘娟谢万华

机构地区陕西省安康市中医医院

出处《吉林医学》 CAS 2015年第3期509-510,共2页 Jilin Medical Journal

关键词同型半胱氨酸糖耐量受损胰岛素抵抗

分类号 R587.1 [医药卫生—内分泌]

引文网络
相关文献

参考文献2

1杨国庆,陆菊明,柳红芳,马芳龄,邹效漫,潘长玉.吡格列酮对胰岛素抵抗大鼠血浆同型半胱氨酸水平的影响[J].中华内科杂志,2005,40(1):38-41. 被引量：46
2郭立新,潘琦,初明峰,郭发金,孙明晓,李慧,李铭,刘小萍.高同型半胱氨酸血症与糖尿病患者颈动脉内膜中层厚度关系及强化控制的影响[J].中华内分泌代谢杂志,2006,22(1):19-22. 被引量：51

二级参考文献25

1卜瑞芳,邓振霞,沈泓,许岚,吴懿玲,蒋艳敏,华嘉临,张稷.血浆同型半胱氨酸水平与2型糖尿病合并脑梗死的关系[J].中华内分泌代谢杂志,2004,20(5):444-445. 被引量：38
2Montalescot G, Ankri A, Chadefanx-Vekemans B, et al. Plasmsa homocysteine and the extent of atherosclerosis in patients with coronary artery disease. Int J Cardial, 1997, 60: 295-300.
3Graham IM, Daly LE, Refsum HM, et al. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA, 1997,277: 1775-1781.
4Gallistl S, Sudi K, Mangge H, et al. Insulin is an independent correlate of plasma homocysteine levels in obese children and adolescents. Diabetes Care, 2000, 23 : 1348-1352.
5Schachter M, Raziel A, Friedler S, et al. Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine. Hum Reprod, 2003,18 : 721-727.
6Fonseca VA, Fink LM, Kern PA. Insulin sensitivity and plasma homocysteine concentrations in non-diabetic obese and normal weight subjects. Atherosclerosls, 2003,167:105-109.
7Fonseca VA, Mudaliar S, Schmidt B, et al. Plasma homocysteine concentration are regulated by acute hyperinsulinemia in nondiabetic but not type 2 diabetic subjects. Metabolism, 1998,47:686-689.
8Dicker-Brown A, Fonseca VA, Fink LM, et al. The effect of glucose and insulin on the activity of methylene tetrahydrofolate reductase andcystathionine-beta-synthase: studies in hepatocytes. Atherosclerosis,2001,158:297-301.
9Jacobs RL, House JD, Brosnan ME, et al. Effect of streptozotocininduced diabetes and of insulin treatment on homocysteine metabolism in the rat. Diabetes, 1998,47 : 1967-1970.
10Fonseca V, Keebler M, Dicker-Brown A, et al. The effect of troglitazone on plasma homocysteine, hepatic and red blood cell Sadenosyl methionine, and S-adenosyl homocysteine and enzymes in homocysteine metabolism in Zucker rats. Metabolism, 2002,51:783-786.