COX-2与Fax、Ki-67在宫颈癌中表达的临床意义

Clinical significance of expressions of COX-2, Fax and Ki-67 in cervical cancer

目的：探讨环氧化酶-2（COX-2）、Fax、Ki-67在宫颈癌中的表达及其临床病理意义。方法采用免疫组织化学染色的方法,检测宫颈癌（cervical cancer, CC）40例,宫颈上皮内瘤变（cervical intraepithelial neoplasm, CIN）10例及正常宫颈组织（normal cervical epithelium, NCE）9例中COX-2、Fax、Ki-67的抗体表达的情况。结果 COX-2在宫颈癌中的表达率为70%-90%,而在正常宫颈组织及宫颈上皮内瘤变中表达率比较差异无统计学意义（P〉0.05）。Fax在宫颈癌中的阳性表达率明显低于正常宫颈组织和CIN组织（P〈0.05）；Ki-67在宫颈癌、CIN与正常宫颈组织中表达差异有统计学意义（P〈0.05）。结论 COX-2、Fax、Ki-67在宫颈癌的发生、发展及淋巴结转移中有着重要作用,可以作为判断宫颈癌恶性程度及淋巴结转移的生物学指标。

Objective To explore the expressions of cyclooxygenase-2 （COX-2）, Fax and Ki-67 in cervical cancer, and their clinical pathological significance. Methods Immunohistochemical staining was applied to examine the antibody expressions of COX-2, Fax and Ki-67 in 40 cases with cervical cancer （CC）, 10 cases with cervical intraepithelial neoplasm （CIN）, and 9 cases with normal cervical epithelium （NCE）. Results The expression rate of COX-2 in CC was 70%-90%, while its expression rate had no statistically significant difference between NCE and CIN （P〉0.05）. The positive expression rate of FAX was obviously lower in the CC than NCE and CIN （P〈0.05）. The difference of expression of Ki-67 between CC, CIN and NCE had statistical significance （P〈0.05）. Conclusion COX-2, Fax and Ki-67 play important roles in the development and progress of cervical cancer, and lymphatic metastasis, and they can act as the biological indicators for judging grade malignancy of cervical cancer and lymphatic metastasis.