血管性认知功能障碍与血脂异常的相关性分析

Correlation analysis and pathogenesis research of dyslipidemia and vascular cognitive impairment

目的分析血管性认知功能障碍与血脂异常的相关性,探讨其发病机制,以行早期预防和治疗。方法 70例血管性认知功能障碍患者作为观察组,70例同期来本院健康检查的健康体检者作为对照组,测定分析两组研究对象的血脂水平;采用简易精神状态检查量表(MMSE)及蒙特利尔认知量表(Mo CA)对观察组患者进行评分。结果观察组患者血清低密度脂蛋白(LDL)、总胆固醇(TC)水平比对照组高,组间差异具有统计学意义(t值分别为4.685、4.135,P<0.05),观察组LDL、TC同MMSE及Mo CA评分比呈负相关(P<0.05)。结论血管性认知功能障碍和血脂异常有着密切的相关性。

Objective To analyze the correlation between dyslipidemia and vascular cognitive impairment, and to explore its pathogenesis, so as to conduct early prevention and treatment. Methods A total of 70 vascular cognitive impairment patients were taken as the observation group, and other 70 healthy people in health examination were taken as the control group. The blood lipid levels was assessed in the two groups, and mini-mental state examination （MMSE） and Montreal cognitive assessment （MoCA） were applied in evaluation of the observation group. Results The observation group had higher levels of low density lipoprotein （LDL） and total cholesterol （TC） than the control group, and the difference had statistical significance between the two groups （t=4.685, 4.135, P〈0.05）. The levels of LDL and TC were negatively correlated with MMSE and MoCA scores （P〈0.05）. Conclusion There is a close correlation between dyslipidemia and vascular cognitive impairment.