美沙拉嗪肠溶片剂联合栓剂治疗活动期直乙结肠型溃疡性结肠炎的疗效分析

Curative effect analysis of mesalazin enteric-coated tablets combined with suppository in the treatment of active stage straight b colon ulcerative colitis

目的美沙拉嗪(5-ASA)肠溶片剂联合栓剂治疗活动期直乙结肠型溃疡性结肠炎(UC)的疗效。方法 80例活动期直乙结肠型溃疡性结肠炎患者,随机分观察组和对照组,各40例。对照组给予美沙拉嗪肠溶片治疗,观察组给予美沙拉嗪肠溶片联合栓剂治疗。观察两组治疗效果和不良反应。结果接受上述治疗2周时,两组治疗总有效率比较差异无统计学意义(P>0.05)。治疗4、6、8周时,两组治疗总有效率比较差异具有统计学意义(P<0.05)。结论口服5-ASA肠溶片与5-ASA栓剂联合使用对我国轻中度UC患者疗效及耐受性良好。

Objective To analyze the curative effect of mesalazin （5-ASA） enteric-coated tablets combined with suppository in the treatment of active stage straight b colon ulcerative colitis （UC）. Methods A total of 80 patients with active stage straight b colon ulcerative colitis were randomly divided into observation group and control group, with 40 cases in each group. The control group received 5-ASA enteric-coated tablets for treatment, and the observation group was treated by 5-ASA enteric-coated tablets combined with suppository. Curative effects and adverse reactions of the two groups were observed. Results After 2 weeks of treatment, there was no statistically significant difference of the total effective rate between the two groups （P〉0.05）. In 4, 6, and 8 weeks of treatment, the difference of the total effective rate between the two groups had statistical significance （P〈0.05）. Conclusion The combination application of oral 5-ASA enteric-coated tablets and 5-ASA suppository can provide good curative effect and tolerance for mild and moderate UC patients in China.