摘要
目的美沙拉嗪(5-ASA)肠溶片剂联合栓剂治疗活动期直乙结肠型溃疡性结肠炎(UC)的疗效。方法 80例活动期直乙结肠型溃疡性结肠炎患者,随机分观察组和对照组,各40例。对照组给予美沙拉嗪肠溶片治疗,观察组给予美沙拉嗪肠溶片联合栓剂治疗。观察两组治疗效果和不良反应。结果接受上述治疗2周时,两组治疗总有效率比较差异无统计学意义(P>0.05)。治疗4、6、8周时,两组治疗总有效率比较差异具有统计学意义(P<0.05)。结论口服5-ASA肠溶片与5-ASA栓剂联合使用对我国轻中度UC患者疗效及耐受性良好。
Objective To analyze the curative effect of mesalazin (5-ASA) enteric-coated tablets combined with suppository in the treatment of active stage straight b colon ulcerative colitis (UC). Methods A total of 80 patients with active stage straight b colon ulcerative colitis were randomly divided into observation group and control group, with 40 cases in each group. The control group received 5-ASA enteric-coated tablets for treatment, and the observation group was treated by 5-ASA enteric-coated tablets combined with suppository. Curative effects and adverse reactions of the two groups were observed. Results After 2 weeks of treatment, there was no statistically significant difference of the total effective rate between the two groups (P〉0.05). In 4, 6, and 8 weeks of treatment, the difference of the total effective rate between the two groups had statistical significance (P〈0.05). Conclusion The combination application of oral 5-ASA enteric-coated tablets and 5-ASA suppository can provide good curative effect and tolerance for mild and moderate UC patients in China.
出处
《中国实用医药》
2014年第36期35-36,共2页
China Practical Medicine