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凝血功能测定在晚期恶性肿瘤患者的临床意义 被引量:7

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摘要 目的对凝血功能测定在晚期恶性肿瘤患者的临床意义进行分析和探讨。方法 176例恶性肿瘤患者作为观察组,同时选取同期80例健康体检者作为对照组,对两组患者的D-二聚体水平以及凝血功能等进行检查。结果与健康对照组相比,观察组患者的TT以及PT延长明显,差异有统计学意义(P<0.05),而D-二聚体水平以及Fib水平显著升高,两组差异具有统计学意义(P<0.05)。相对于健康对照组而言,观察组患者的APTT水平差异无统计学意义(P>0.05)。结论在对恶性肿瘤患者的高凝状态进行观测的时候,检测恶性肿瘤患者的D-二聚体水平以及Fib具有一定的意义。
出处 《中国实用医药》 2014年第36期78-79,共2页 China Practical Medicine
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  • 1Franchini M, Montagnana M, Targher G, et al. Pathogenesis, clinical and laboratory aspects of thrombosis in cancer. J Thromb Thrombolysis, 2007, 24( 1 ) :29-38.
  • 2Bobek V, Kovarfk J. Antitumor and antimetastatic effect of warfarin and heparins. Biomed Pharmacother, 2004, 58(4) : 213-219.
  • 3Cunningham MS, White B, O' Donnell J. Prevention and management of venous thromboembolism in people with cancer: a review of the evidence, Clin Oncol, 2006,1 8(2) : 145-151.
  • 4Oktar GL, Ergul EG, Kiziltepe U. Occult malignancy in patients with venous thromboembolism: risk indicators and a diagnostic screening strategy. Phlebology, 2007, 22(2):75-79.
  • 5Bergqvist D, Caprini JA, Dotsenko O, et al. Venous Thromboembolism and Cancer. Curr Probl Surg, 2007, 44(3) : 157-216.
  • 6Vlodavsky I,Ilan N, Nadir Y, et al. Heparanase, heparin and the coagulation system in cancer progression. Thromb Res, 2007, 120 suppl 2:S112-120.
  • 7Viale PH. Abnormal clotting in cancer: an overview of pathophysiology and etiology. Semin Oncol Nuts, 2005, 21(4 suppl 1) : 12-20.
  • 8Zwicker JI, Furie BC, Furie B. Cancer-associated thrombosis. Crit Rev Oncol Hematol, 2007, 62(2) : 126-136.
  • 9Versteeg HH, Schaffner F, Kerver M, et al. Inhibition of tissue factor signaling suppresses tumor growth. Blood, 2008,111 ( 1 ) :190-199.
  • 10Hobbs JE, Zakarija A, Cuudiff DL, et al. Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model. Thromb Res, 2007,120 suppl 2:s13- 21.

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  • 1Morgan DE, Waggoner CN, Canon CL, Lockhart ME, Fine-berg NS, Posey JA, Vickers SM. Resectability of pancreatic adenocarcinoma in patients with locally advanced disease downstaged by preoperative therapy : a challenge for MDCT [ J ]. A JR Am J Roentgenol,2010,19 (194) : 615--622.
  • 2Oya M, Akiyama Y, Okuyama T, et al. High preoperative plasma D- dimer level is associated with advanced tumor stage and short surviv- al after curative resection in patients with colorectal cancer[ J]. Jpn J Clin Oncol,2001,11 (31) : 388-394.
  • 3Nagy Z, Horv6th O, K6das J, et al. D-dimer as a potential prognostic marker[ J]. Pathol Oncol Res,2012,30(18) : 669-674.
  • 4Thaler J, Ay C, Mackman N, et al. Microparticle-associated tissue factor activity, venous thromboembolism and mortality in pancreatic, gastric, colorectal and brain cancer patients[ J]. J Thromb Haemost, 2012,35(10) : 1363-1370.
  • 5Durczyfiski A, Szymafaski D, Nowicki M, et al. Very high concentra- tion of D-dimers in portal blood in patients with pancreatic cancer [ J]. Pal Przegl Chit,2012,84 : 521-525.
  • 6余新春,吴善水,陆晓青,盛李明,胡雅国,赵健,李娟梅,邵海燕.外周血血小板计数与食管癌临床病理相关性研究[J].浙江大学学报(医学版),2009,38(2):170-173. 被引量:2
  • 7张志国,韩磊,赵丽波.恶性肿瘤与血栓栓塞性疾病[J].实用肿瘤杂志,2010,25(3):346-348. 被引量:16
  • 8张瑜,杨宁蓉,王锋,廖峰,龚新雷,王琳.晚期恶性肿瘤患者凝血功能及D-二聚体水平检测的临床意义[J].实用癌症杂志,2012,27(2):165-167. 被引量:43
  • 9程少会,曹军丽,付占昭.不同肿瘤患者血浆D-二聚体水平及临床意义[J].临床荟萃,2013,28(1):88-89. 被引量:10
  • 10姜国庆,龚军,俞小炯.胰腺癌手术方式研究进展[J].实用医院临床杂志,2013,10(3):155-158. 被引量:15

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