尼莫地平泊洛沙姆188纳米胶束的制备工艺研究

Study on preparation of nimodipine loaded pluronic 188 nano-micelles

目的探讨制备尼莫地平泊洛沙姆188纳米胶束的优良工艺。方法采用乳化-溶剂蒸发法制备尼莫地平泊洛沙姆188纳米胶束,考察影响尼莫地平泊洛沙姆188纳米胶束包封率的主要因素,即有机溶剂的种类、尼莫地平溶液滴加速率、有机相与水相的体积比以及尼莫地平与泊洛沙姆188的质量比,并在此基础上采用正交设计优化尼莫地平泊洛沙姆188纳米胶束的制备工艺。结果尼莫地平泊洛沙姆188纳米胶束的制备最优处方为尼莫地平滴加速率为0.2 ml/min,有机相与水相的体积比为1∶5,尼莫地平与泊洛沙姆188的质量比为1∶3。结论通过正交试验,能够获得尼莫地平泊洛沙姆188纳米胶束的最佳制备工艺。

Objective To investigate the superordinary technology of preparing pluronic 188 nano-micelles loaded with nimodipine. Methods Nimodipine loaded pluronic 188 nano-micelles were prepared by emulsifying solvent-evaporation method.The main factors effecting the drug encapsulation ratio were investigated,the factors include the kinds of organic solvent,the dropping rate of nimodipine solution,the volume ratio of organic phase to aqueous phase and the mass ratio of nimodipine to poloxamer 188,on the basis of single-factor experiments,the orthogonal design was carried out to optimize the preparation of nimodipine loaded pluronic 188 nano-micelles. Results The optimal preparation of nimodipine loaded pluronic 188 nano-micelle was： the nimodipine dropping rate was 0.2 ml/min,the volume ratio of organic phase to aqueous phase was 1∶5 and the mass ratio of nimodipine to poloxamer 188 was 1∶3. Conclusion Superordinary technology of preparing nimodipine loaded pluronic 188 nano-micelles can be obtained by orthogonal design.