腹腔镜下穿孔修补联合高选择性迷走神经切断术治疗十二指肠溃疡的临床效果观察

The clinical curative efficacy of laparoscopic repair of perforation combined with high selective vagotomy in the treatment of duodenal ulcer

目的探讨腹腔镜下穿孔修补联合高选择性迷走神经切断术治疗十二指肠溃疡的临床效果。方法以本院2008年9月-2014年5月收治的103例十二指肠溃疡患者为研究对象,按照治疗方法分成对照组（46例）和观察组（57例）,对照组采取腹腔镜下穿孔修补术,观察组采取腹腔镜下穿孔修补联合高选择性迷走神经切断术,比较两组的临床疗效。结果观察组手术时间、手术出血量与对照组比较,差异无统计学意义（P〉0.05）;观察组住院时间明显短于对照组（P〈0.05）;观察组术后1年最大酸排出量明显少于对照组（P〈0.05）。观察组痊愈率高于对照组,复发率和并发症发生率低于对照组,差异有统计学意义（P〈0.05）。结论腹腔镜下穿孔修补联合高选择性迷走神经切断术治疗十二指肠溃疡的临床效果明显,值得进一步推广应用。

Objective To investigate the clinical effect of laparoscopic repair of perforation combined with high selective vagotomy in the treatment of duodenal ulcer. Methods 103 cases of patients with duodenal ulcer treated in our hospital from September 2008 to May 2014 were selected and were divided into control group（46 cases） and observation group（57 cases）.Laparoscopic repair of perforation was taken to the control group,laparoscopic perforation repair combined with highly selective vagotomy was taken to the observation group.The clinical efficacy of two groups was compared. Results The operation time and operation bleeding of two groups had no significant difference（P〉0.05）;the hospitalization time of the observation group was shorter than that of the control group（P〈0.05）;After 1 year,the maximum acid output of the observation group was less than that of the control group（P〈0.05）.The cure rate of the observation group was higher than that of the control group,recurrence rate and complication rate was lower than that of the control group,the difference was significant（P〈0.05）. Conclusion Laparoscopic repair of perforation combined with high selective vagotomy has an obvious curative effect,which is worthy of popularization and application.