子宫内膜异位症术后米非司酮和孕三烯酮治疗效果的对比分析

Analysis of treatment Effect comparision of mifepristone and gestrinone after surgery of endometriosis

目的探讨子宫内膜异位症术后应用米非司酮和孕三烯酮的治疗效果。方法将120例盆腔子宫内膜异位症手术患者,按照住院顺序编号,单号为孕三烯酮组,2.5 mg/次,2次/周,口服给药。双号为米非司酮组,给予12.5 mg/次,1次/d,口服给药。对比分析两组的治疗效果。结果米非司酮组的治疗效果明显优于孕三烯酮组,差异有统计学意义(P<0.05);两组治疗后的血清P水平较治疗前明显下降,差异有统计学意义(P<0.05)。两组患者治疗前后的FSH、LH、E2、PRL水平无明显变化,差异无统计学意义(P>0.05);米非司酮组和孕三烯酮组出现恶心症状的患者分别有8例(13.33%)和25例(41.67%),差异有统计学意义(P<0.05)。结论子宫内膜异位症术后使用米非司酮的治疗效果较孕三烯酮好。

Objective To investigate the treatment effect of mifepristone and gestrinone applied after surgery of endometriosis. Methods 120 cases with pelvic endometriosis were numbered according to hospitalization sequence,odd numbers were the gestrinone group,2.5 mg every time, twice a week,oral administration,while even numbers were the mifepristone group,and the patients were given oral mifepristone 12.5 mg every time, once a day.The treatment effect of both groups were compared and analyzed. Results The treatment effect of the mifepristone group was obviously better than that of the gestrinone group,the difference was statistically significant（P〈0.05）;The serum level of P in both groups were significantly lower than that before treatment,the difference was statistically significant（P〈0.05）.The serum level of FSH,LH,E2,PRL in both groups were no significant difference（P〈0.05）.Nausea symptom of the mifepristone group were8 cases（13.33%） and the gestrinone group were 25 cases（41.67%）,the difference was statistically significant（P〈0.05）.Conclusion The postoperative application of mifepristone to treating endometriosis can gain better effect than gestrinone.