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钙结合蛋白S100A12在类风湿关节炎发病及诊疗中的作用 被引量：1

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摘要 对近年来钙结合蛋白S100A12与类风湿关节炎的相关研究进行综述,钙结合蛋白S100A12与类风湿关节炎的病理过程等相关,可能存在一定的促炎作用,或为患者炎症的潜在标志,辅助评估疾病的活动度。
作者 罗丹 乔森焱 易小烈 肖诚
机构地区 中日友好医院 北京中医药大学 桂林医学院 黔西县中心医院 宜春市人民医院
出处 《风湿病与关节炎》 2015年第1期58-62,共5页 Rheumatism and Arthritis
基金 科技部国际合作项目(2014DFA31490) 国家自然科学基金(81373773) 北京市自然科学基金(7142144)
关键词 关节炎 类风湿 S100A12 晚期糖基化终末产物受体 炎症 综述
分类号 R593.22 [医药卫生—内科学]
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参考文献27

  • 1王海浪,王巧民.S100钙结合蛋白A12在炎症性肠病中的研究进展[J].胃肠病学,2012,17(1):50-52. 被引量：1
  • 2Meijer B,Gearry RB,Day AS.The role of S100A12 as a systemic marker of inflammation I J ] .Int J In- flam,2012:907078.
  • 3Moroz OV,Blagova EV,Wilkinson AJ,et al.The crystal structures of human S100A12 in apo form and in corn-plex with zinc: new insights into $100A12 oligomerisa- tion [J] .J Mol Biol,2009,391 ( 3 ) :536-551.
  • 4Hsu K,Champaiboon C,Guenther BD,et al.Anti-infec- tive protective properties of S100 calgranulins [ J ] . Antiinflamm Antiallergy Agents Med Chem,2009,8 ( 4 ) :290-305.
  • 5Reis RA,Bortot LO,Caliri A.In silico assessment of S100A12 monomer and dimer structural dynam- ics:implications for the understanding of its metal-in- duced conformational changes [ J ] .J Biol Inorg Chem,2014,19 (7) :1113-1120.
  • 6Moroz OV,Burkitt W,Wittkowski H,et al.Both Ca2. and Zn2 are essential for S100A12 protein oligornerization and function [ J ] .BMC Biochem,2009 ( 10 ) :11.
  • 7Perera C,McNeil HP,Geczy CL.S100 Calgranulins in inflammatory arthritis [J] .Immunol Cell Biol,2010,88 ( 1 ) :41-49.
  • 8Pietzsch J,Hoppmann S.Human S100A12:a novel key player in inflammation? [ J ] .Amino Acids,2009,36 ( 3 ) : 381-389.
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二级参考文献20

  • 1Garcia AF,Garcia W,Nonato MC,et al.Structural stability and reversible unfolding of recombinant porcine S100A12. Biophys Chem,2008,134(3):246-253.
  • 2Santamaria-Kisiel L,Rintala-Dempsey AC,Shaw GS.Calcium-dependent and-independent interactions of the S100 protein family.Biochem J,2006,396(2):201-214.
  • 3Eckert RL,Broome AM,Ruse M,et al.S100 proteins in the epidermis.J Invest Dermatol,2004,123(1):23-33.
  • 4Robinson MJ,Hogg N.A comparison of human S100A12with MRP-14(S100A9).Biochem Biophys Res Commun,2000,275(3):865-870.
  • 5Foell D,Ichida F,Vogl T,et al.S100A12(EN-RAGE)in monitoring Kawasaki disease.Lancet,2003,361(9365):1270-1272.
  • 6Foell D,Kane D,Bresnihan B,et al.Expression of the pro-inflammatory protein S100A12(EN-RAGE)in rheumatoid and psoriatic arthritis.Rheumatology (Oxford),2003,42(11):1383-1389.
  • 7Leach ST,Yang Z,Messina I,et al.Serum and mucosal S100 proteins,calprotectin(S100A8/S100A9)and S100A12,are elevated at diagnosis in children with inflammatory bowel disease.Scand J Gastroenterol,2007,42(11):1321-1331.
  • 8Mikkelsen SE,Novitskaya V,Kriajevska M,et al.S100A12 protein is a strong inducer of neurite outgrowth from primary hippocampal neurons.J Neurochem,2001,79(4):767-776.
  • 9Gottsch JD,Eisinger SW,Liu SH,et al.Calgranulin C has filariacidal and filariastatic activity.Infect Immun,1999,67(12):6631-6636.
  • 10Hsieh HL,Sch(a)fer BW,Weigle B,et al.S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells.Biochem Biophys Res Commun,2004,316(3):949-959.

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风湿病与关节炎
2015年 第1期

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