化瘀软肝汤治疗代偿期乙型肝炎肝硬化的疗效观察

Clinical Effect of Huayu Ruangan Decoction in Treating Decompensated Hepatitis B Cirrhosis

目的探讨中药化瘀软肝汤治疗代偿期乙型肝炎肝硬化临床疗效。方法将代偿期乙型肝炎肝硬化患者80例随机分为对照组及治疗组各40例,对照组给予抗病毒、保肝、降酶、退黄药物等综合治疗,治疗组在对照组基础上加用化瘀软肝汤,200ml/次,3次/日,疗程6个月,疗程结束后观察6个月,生化法检测肝纤维化指标透明质酸(HA)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(Ⅳ-C)、层粘连蛋白(LN),B超检测肝脏门静脉、脾静脉的直径和脾脏大小。结果治疗组总有效率为88.6%,对照组总有效率为67.5%,治疗组总有效率显著高于对照组(P<0.05);治疗组肝纤维化检测以及B超影像学(门静脉、脾静脉直径和脾脏长径)各项目指标均低于对照组,差异有统计学意义(P<0.05)。结论化瘀软肝汤治疗代偿期乙型肝炎肝硬化临床疗效显著。

Objective To investigate the clinical effect of Huayu Ruangan decoction in treating decompensated hepatitis B cirrhosis. Methods Eighty cases of decompensated liver cirrhosis patients were randomly divided into control group and treatment group with forty cases in each group. Patients in the control group were given anti-vi-rus, conventional protecting liver, reducing enzyme and jaundice treatment. The patients of treatment group were treated with Huayu Ruangan decoction on the basis of treatment of the control group. The therapy course lasted for 6 months. The clinical effect and fibrosis index of hyaluronic acid （HA）, procollagen Ⅲ （PC-Ⅲ ）, type Ⅳ colla-gen（Ⅳ-C）, laminin（LN）and the hepatic portal vein, splenic vein and splenic size width were observed. Results Af-ter treatment the total effective rate of treatment group was 88. 6%, control group was 67. 5%, treatment group had obviously superiority than that of control group（P〈0. 05）.The fibrosis index（HA, PC-Ⅲ, Ⅳ-C, LN）and the hepatic portal vein, splenic vein and splenic size width were lower than those of the control group. Conclusion The clinical efficacy of Huayu Ruangan decoction in treating hepatitis B cirrhosis is remarkable.