三联方案治疗Hp阳性消化性溃疡的疗效评价

Evaluation of Curative Effect of Triple Regimen in The Treatment of Hp Positive Peptic Ulcer

目的探究甲硝唑、阿莫西林克拉维酸钾和奥美拉唑三联方案治疗幽门螺杆菌(Helicobacter pylori,Hp)感染阳性型消化性溃疡的效果,指导临床合理用药。方法随机选我院收治的Hp阳性消化性溃疡患者共190例,其中单用奥美拉唑治疗的95例患者作对照组,同时联用甲硝唑和阿莫西林克拉维酸钾的95例患者作观察组,对比两组患者疗效及不良反应。结果观察组总有效率(96.84%)显著高于对照组(84.21%),P<0.05,存在显著性差异。结论甲硝唑、阿莫西林克拉维酸钾和奥美拉唑三联方案能够有效治疗Hp阳性消化性溃疡,建议临床普及应用。

Objective To explore the clinical effect of metronidazole, amoxicillin and clavulanate potassium and omeprazole for Helicobacter pylori （Hp） infection positive type peptic ulcer, to guide the clinical rational drug use. Methods 190 cases with Hp positive peptic ulcer were selected randomly in Benxi Central Hospital, control group （95 cases） received only omeprazole, and observation group（95 cases） were treated with metronidazole, amoxicillin and clavulanate potassium and omeprazole, and the clinical effect and adverse reaction were compared between two groups. Results The total effective rate of observation group （96.84%） was signiifcantly higher than that of the control group （84.21%）, P〈0.05, the difference had statistical significance. Conclusion Metronidazole, amoxicillin and clavulanate potassium and omeprazole triple therapy had remarkable effective in the treatment of Hp positive peptic ulcer. It was worthy of clinical promotion and application.