盐酸舍曲林对冠心病合并抑郁患者治疗作用的临床研究

To Investigate the Clinical Curative of Sertraline on Treatment of Coronary Heart Disease Combines Depression

目的:评价盐酸舍曲林治疗冠心病(CHD)合并抑郁患者的临床疗效。方法:选取CHD合并抑郁患者98例,随机分成舍曲林治疗组49例和对照组49例。治疗组在常规CHD药物治疗的基础上,加服抗抑郁药舍曲林50mg,每日一次,疗程8周。结果:8周后,治疗组HAMD评分、SDS评分与对照组比较,差别有显著统计学意义(P<0.001),治疗组死亡率、心梗再发率、心律失常发生率比较对照组明显降低(P<0.05),且心肌缺血改善优于对照组(P<0.001)。结论:舍曲林治疗CHD合并抑郁症患者的近期临床疗效显著。

Objective：To evaluate the clinical curative of sertraline on treatment of coronary heart disease（CHD）combines depression.Methods：98patients with CHD combine depression were randomly separated into sertraline group（n=49）and control group（n=49）.Sertraline group received sertraline 100 mg once per day based on the routine care,the course of treatment lasts 8weeks.Results：After 8weeks,there was significant difference between sertraline group and control group in HAMD score and SDS score.The mortality,rate of repeat myocardial infarction,and the incidence of arrhythmia in the sertraline group was significantly decreased compared with control group;in addition,myocardial ischemia symptom was improved in sertraline group.Conclusion：The clinical curative of sertraline shows prominent effect on the treatment of coronary heart disease combined with depression.