生脉注射液预防心脏直视术后继发便秘21例

Shengmai injection preventing constipation after cardiac surgery

目的：探讨生脉注射液预防心脏直视术后继发便秘的临床疗效及机制。方法：本课题纳入风湿性左心二尖瓣和／或主动脉瓣瓣膜病变的30～80岁欲行体外循环下心脏直视手术患者42例为研究对象，随机分为治疗组和对照组，各21例。治疗组给予生脉注射液治疗。对比两组患者术后排便情况的差异。通过酶联免疫法检测三种胃肠激素的变化。结果：心脏直视手术后，生脉治疗组的便秘发病率显著低于对照组（P＜0．05）；生脉治疗组和对照组相比较，术后第1d、第3d、第6d ，治疗组VIP、SS浓度水平显著低于对照组（P值均＜0．05）；治疗组SP浓度水平显著高于对照组（P值均＜0．05）。结论：生脉注射液能有效降低心脏直视手术后便秘的发病率；生脉注射液能有效降低术后VIP、SS浓度水平，提高SP浓度水平。

Objective：Through clinical contrast experiment to observe the clinical curative effect of Shengmai Injection preventing constipation after cardiac surgery .Methods ：In the experiment ,we selected 42 cases with rheumatic heart value disease who will do open heart surgery under CPB .We randomly divided into experimental group and the con‐trol group ,21 cases each .Contrasting the differences of defecation situation between two groups .By enzyme‐linked im‐munoassay detection three changes of gastrointestinal hormones .Results：After open heart surgery ,the incidence of the experimental group was significantly lower than that in control group（P〈0 .05）;Postoperative day 1 ,day 3 ,day 6 ,the VIP ,SS concentration of experimental group was significantly lower than that in control group （all P values 〈 0 .05） .The SP concentration of experimental group was significantly higher than that in control group （all P values 〈 0 .05） .Conclu‐sion：Shengmai injection can effectively prevent constipation after cardiac surgery ,reduce the incidence of constipation ;Shengmai injection can effectively reduce the postoperative levels of VIP ,SS ,improve the level of SP .