冠心病阿司匹林抵抗的研究与对策

Progress of aspirin resistance in patients with coronary heart disease

阿司匹林是冠心病患者长期抗血小板治疗的基石,同其他抗血小板药物一样,阿司匹林也存在抗血小板药物抵抗现象,若发生阿司匹林抵抗,可能会增加冠心病患者心血管事件风险。目前已有多项研究对抗血小板药物抵抗进行了探究,文章针对阿司匹林抵抗的定义、相关机制、实验室检测、临床影响及可能有效的治疗干预措施等研究进展进行概述,旨在提高临床医生对阿司匹林抵抗的认识,并科学优化冠心病患者的抗血小板治疗。

Aspirin is the vital antiplatelet agents for patients with coronary heart disease. Like other antiplatelet drugs, aspirin is also found with antiplatelet resistance or variability of platelet response, Aspirin resistance（AR） may increase the risk of recurrent cardiovascular events in patients with coronary heart disease. Resistance to anti-platelet therapy has received extensive coverage in the literature. In this article we will review and analyze the concept of AR, possible mechanisms, laboratory measurements, clinic significance, and preventive strategies from recent researches in order to improve the understanding of AR and help to optimize antiplatelet therapy for coronary heart disease patients.