摘要
变态反应性疾病和风湿性疾病是儿童时期常见的免疫系统紊乱性疾病,其特点为发病率逐年上升,病程长,易反复,不利于患儿病情恢复,明显影响疾病的预后。既往经典的Th1/Th2理论认为:Th1介导的风湿性疾病和Th2介导的变态反应性疾病在免疫机制及发病情况上相互补充,从而出现体内原本失衡的T细胞亚群达到新的平衡,改善了患儿的预后。而近年的研究发现对该理论提出了新的挑战,认为变态反应性疾病和风湿性疾病无论在发病机制还是在临床表现方面均互为危险因素。因此,阐明两者的关系有利于指导临床的诊疗和预后判断。本文拟结合国内外研究进展,把儿童变态反应性疾病对风湿性疾病的影响进展做一阐述。
Allergic disorders and rheumatic diseases are twocommon diseases of dysregulated immune system in children,with the feature of long disease course and easy relapse,andthe incidence of the two diseases is increasing. All these features are bad for the prognosis of children with the diseases.Prior Th1/Th2 theory deemed that Th1-mediated autoimmunediseases and Th2-mediated allergic conditions are complementary both on the mechanism and incidence,which improve patients＇ outcomes with a new balance of T cell subsets. Recentstudies,however,have served to challenge the idea that thepresence of allergy and autoimmunity are mutually exclusivestates and suggest that allergic diseases and rheumatic diseases are risk factors for each other. Clear understanding of the re-lationship between children＇s rheumatic diseases and allergicdisorders will have important implications for clinical treatment and diagnosis. This article clarifies the influence of allergic diseases on children＇s rheumatic disease.
出处
《中国实用儿科杂志》
CSCD
北大核心
2015年第1期17-20,共4页
Chinese Journal of Practical Pediatrics
基金
上海市中医药事业发展三年行动计划第二批重大研究项目(ZYSNXD-CC-ZDYJ030)
