腺苷酸活化蛋白激酶途径与肿瘤的研究进展

Advance in Research on the Relationship between Adenosine Monophosphate Activated Protein Kinase Signaling Pathway and Tumor

腺苷酸活化蛋白激酶(AMPK)是哺乳动物细胞中高度保守的蛋白质,是细胞的重要的代谢感受器。哺乳动物雷帕霉素靶蛋白(m TOR)信号通路,是一种不典型的丝/苏氨酸激酶,在进化中也具有高度保守性,主要通过调控蛋白合成来调节细胞的生长,m TOR激酶通过多种信号通路来实现对细胞生长的调节作用,其中营养信号激活通路为细胞外的氨基酸通路LKB1-AMPK途径。二甲双胍(LKB1/AMPK的激活剂),可抑制m TOR的活性,从而可以应用于多种肿瘤的治疗,目前研究表明AMPK信号通路及其相关的信号通路与多种肿瘤的发生、发展有关。

Adenosine Monophosphate Activated Protein Kinase（AMPK） is a highly conservative protein in mammals＇ cells,and it is an important metabolic receptor of cells.The signal pathway of mammals＇ mTOR is an atypical silk/threonine kinase,even when it is in the process of anagenesis,it is highly conservative,and it controls the growth of cells through regulating protein synthesis.It is through many kinds of signal pathway that mTOR controls the growth of cells,among which,nutrition signal activation pathway is the channel of amino acid pathway outside the cells.Metformin （the activating agent of LKB1/AMPK） can inhibit the activity of mTOR and thus can be used in the treatment of many kinds of malignancy.The latest study shows that the signal pathways of AMPK and the relevant signal pathways are connected with the occurrence and development of many tumors.