糖尿病患者心血管疾病发病机制的研究进展

Research Progress on the Pathogenesis of Cardiovascular Disease in Patients with Diabetes

多项流行病学研究证实,糖尿病是包括心肌梗死、卒中、外周血管疾病及心力衰竭在内的各种心血管疾病发生、发展的主要危险因素。糖尿病患者中动脉粥样硬化和心血管疾病患病率逐渐升高,可能是多种因素所致。在这个过程中可能的机制包括直接和间接影响高血糖和糖基化终末产物、血管内皮功能受损、增加亚临床炎症和血栓形成和纤溶异常。因此,为了减少糖尿病的卫生负担有必要积极地预防和治疗心血管疾病。

It has been demonstrated by multiple epidemiologic studies that diabetes is a major risk factor for the incidence and development of all kinds of cardiovascular diseases,including myocardial infarction,stroke,peripheral vascular disease,and heart failure.Incidence rates of atherosclerosis and cardiovascular diseases in patients with diabetes have been gradually increasing,and the causes are multifactorial.Potential mechanisms involved in this process include the direct and indirect effects of hyperglycemia and advanced glycation end products,impaired endothelial function,increased subclinical inflammation,and abnormalities of thrombosis and fibrinolysis.Therefore,it is necessary to positively prevent and treat cardiovascular diseases in order to release the burden of healthcare for diabetes patients.