6分钟步行试验与糖尿病外周动脉疾病的相关性研究

Study on the Relationship between 6-minute Walking Test and Peripheral Arterial Disease in Diabetic Patients

目的 明确6 min步行试验（6MWT）距离用于诊断糖尿病外周动脉疾病（PAD）的价值,探讨6MWT作为PAD初筛指标的可行性.方法 选择2012年1～12月上海市第一人民医院分院门诊及住院的2型糖尿病患者160例作为研究对象,患者分别进行踝臂指数（ABI）检测以及6MWT,探讨两者的相关性.结果 不同ABI值的2型糖尿病患者的6MWT比较,差异有统计学意义（t=11.99,P＜0.05）,且6MWT与ABI呈正相关（r=0.827,P ＜0.01）;受试者工作特征曲线分析显示6MWT对PAD（以ABI＜0.9为标准）有鉴别价值（药时曲线下面积为0.936,P＜0.01）,当将6MW距离＜408 m 时,其诊断PAD的灵敏度和特异度分别为90.8％和88.4％.结论 6MWT检测简单、方便、安全、康价,适合相对“健康”的糖尿病患者进行早期的PAD筛查.

Objective To identify the value of 6-minute walking test （6MWT） in diagnosing peripheral arterial disease （PAD） of diabetic patients and explore the feasibility of using 6MWT to prescreen PAD.Methods A total of 160 patients with type 2 diabetes admitted in Shanghai First People＇s Hospital from Jan.to Dec.2012 were selected as objects.The patients received both 6-MWT and ankle brachial index （ABI） measurement,and the correlation between the two results were analyzed.Results The 6MWT values of diabetic patients with different ABI values had statistically significant differences （t =11.99,P 〈 0.05）,6MWT value and ABI value showed positive correlation in diagnosing PAD（r =0.827,P 〈0.001）.Receiver operating characteristic（ROC） curves confirmed that 6MWT could significantly differentiate PAD（AUC =0.936,P 〈0.01）.When 6MWT 〈 408 m,its sensitivity of diagnosing PAD was 90.8%,and the specificity was 88.4%.Conclusion 6MWT is simple,convenient,safe and cheap,it＇s feasible for early screening of PAD in mild diabetic patients.