摘要
目的:观察99Tc-MDP(云克)对骨性关节炎患者治疗前后症状、细胞因子水平、骨侵蚀修复及骨密度的变化情况,探讨云克治疗骨关节炎的临床价值。方法:选择我科2009年1月-2012年3月住院的106名骨关节炎患者;其中,男49例,女67例,平均年龄(62.5±14.2)岁;随机分为2组,传统治疗组和云克治疗组,分别进行治疗前的对关节疼痛数量,IL-1β、TNF-α水平和跟骨密度水平指标进行检测,观察治疗3周之后关节疼痛数量,IL-1β、TNF-α水平和骨关节面的骨侵蚀修复情况,并进行统计比较。结果:治疗前后两组间各项指标均具有统计学意义(P<0.01)。结论:联合使用云克治疗骨关节炎,可以明显改善病情,降低细胞因子水平,促进骨关节面修复的作用。
Objective: To observed the changes of condition changes,cytokines (IL-1β, TNF-α) levels,bone erosion repair and bone mineral density,before and after ^99Tc-MDP (MDP) treatment osteoarthritis and explore the clinicalvalue use of MDP treatment osteearthritis. Methods: Select 106 patients hospitalized osteearthritis in our department from January 2009 to March 2012 Among them, 49 males and 67 females, mean age (62.5±14.2)years,randomly divided into 2 groups,respectively, to maintain the originaltreatment group and the MDP group therapy for three weeks; The number of joint pain,IL-1β,TNF-α levels and level indicators with BMD were detected before treatment, observation and treatment of bone and joint pain quantity,IL-1β,TNF-α levels and bone and joint surfaces after 3 weeks erosion repair the situation and make statistical comparisons. Results:Indicators before and after treatment between the two groups were statistically significant (P〈0.01). Conclusion:The combined use of cloud g treatment of osteoarthritis, can significantly improve the condition and reduce the levels of cytokines, promote articular surface repair.
出处
《甘肃医药》
2015年第1期31-33,共3页
Gansu Medical Journal