戈谢氏病伴血小板减少一例并文献复习

A case report of Gaucher disease with thrombocytopenia and literature review

目的：探讨骨髓细胞形态学检查在戈谢氏病诊断中的价值。方法：采用瑞氏一吉姆萨染色法、糖原染色法对一例戈谢氏病伴血小板减少患者的骨髓片、血片进行化学染色，辅助骨髓基因及染色体检查，结合文献复习，提高对该病的认识。结果：瑞氏一吉姆萨染色发现骨髓片中的戈谢氏细胞，糖原染色该细胞呈阳性反应，确诊为戈谢氏病。结论：骨髓细胞形态学检查有助于戈谢氏病的早期诊断。

Objective ： To investigate the value of the cellular morphologic detection of bone marrow in the Gaucher disease. Methods ： The bone marrow slides of a patient of the Gaucher disease with thrombocytopenia were used respectively by the Wright- Giemsa staining and the periodic acid-Schiffreaction （PAS）. The blood slides were used by the Wright-Giemsa staining. The detection of gene and chromosome of the bone marrow were aided diagnosis to the Gaucher disease. The related literatures were reviewed.Results ： The Gaucher cells were detected in the bone marrow slides by the .Wright-Giemsa staining. These cells were also positive reaction in the PAS. Then the patient was diagnosed the Gaucher disease. Conclusions ： The cellular morphologic detection of bone marrow may play a role in the early diagnosis of the Gaucher disease.