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Role of BDNF in the taste system

Role of BDNF in the taste system
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摘要 Neurotrophins are a family of proteins that regulate neural survival, development, function and plasticity in the central and the peripheral nervous system. There are four neurotrophins： NGF, BDNF, NT-3 and NT-4. Among them, BDNF is mostly studied in the taste system due to its high expression. Recent studies have shown BDNF play an important role in the developmental and mature taste system, by regulating survival of taste cells and geniculate ganglion neurons, and maintaining and guiding taste nerve innervations. These studies imply BDNF has great potentialities for therapeutic usage to enhance sensory regeneration following nerve injury, with aging, and in some neurodegenerative diseases. Neurotrophins are a family of proteins that regulate neural survival, development, function and plasticity in the central and the peripheral nervous system. There are four neurotrophins： NGF, BDNF, NT-3 and NT-4. Among them, BDNF is mostly studied in the taste system due to its high expression. Recent studies have shown BDNF play an important role in the developmental and mature taste system, by regulating survival of taste cells and geniculate ganglion neurons, and maintaining and guiding taste nerve innervations. These studies imply BDNF has great potentialities for therapeutic usage to enhance sensory regeneration following nerve injury, with aging, and in some neurodegenerative diseases.
作者 Lingbin MENG Xiaolei CHEN Rongqiang YANG Rui JI
机构地区 Department of Anatomical Sciences and Neurobiology Department of Chemistry Department of Biochemistry and Molecular biology
出处 《Frontiers in Biology》 CAS CSCD 2014年第6期481-488,共8页 生物学前沿（英文版）
关键词 brain-derived neurotrophic factor （BDNF） taste bud geniculate ganglion chorda tympani nerve brain-derived neurotrophic factor （BDNF）, taste bud, geniculate ganglion, chorda tympani nerve
分类号 Q421 [生物学—神经生物学] Q42 [生物学—神经生物学]
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Frontiers in Biology
2014年 第6期

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