血尿酸和胆红素水平与冠状动脉粥样硬化的关系探讨

The relationship between the coronary atherosclerosis and the levels of blood uric acid as well as the bilirubin

目的探讨血尿酸(uric acid,UA)和胆红素水平与冠状动脉粥样硬化(coronary atherosclerosis,CA)的相关性。方法选择2012年1月至2014年1月我院98例CA患者为病例组,根据冠状动脉病变程度分为单支病变组和多支病变组,同期选择64例健康体检者为健康对照组,检测受试者UA、总胆红素(total bilirubin,rBIL)、直接胆红素(direct bilirubin,DBIL)和间接胆红素(indirect bilirubin,IBIL,)水平,对检测结果进行统计学分析。结果 CA患者组的UA水平高于健康对照组,差异有统计学意义(P<0.05)。CA患者组的FBIL、DBIL和IBIL水平均低于健康对照组,且差异均有统计学意义(P均<0.05);多支病变组患者的UA水平高于单支病变组,且差异有统计学意义(P<0.05),多支病变组患者的TBIL、IBIL水平均低于单支病变组,且差异均有统计学意义(P均<0.05),多支病变组患者的DBIL水平虽低于单支病变组,但两组间差异无统计学意义(P>0.05);UA、FBIL、DBIL和IBIL水平与冠状动脉狭窄程度的相关系数r分别为0.907、-0.884、-0.867和-0.859(P均<0.05)。结论高UA和低血胆红素水平是CA的危险因素,可作为CA的辅助诊断指标。

Objective To research the relationship between the coronary atherosclerosis （CA） and the blood uric acid （UA） as well as the bilirubin. Methods 98 cases of patients with CA and 64 cases of healthy controls from January 2012 to January 2014 in our hospital were collected. The CA patients were divided into single vessel lesion group and multiple vessel lesion group according to the lesion degree of coronary artery. The blood UA, total bilirubin （TBIL）, direct bilirubin （DBIL） and indirect bilirubin （IBIL） levels of all the sub- jects were detected, and the results were analyzed statistically. Results The blood UA level of CA group was significantly higher than that of the healthy control group, and the difference had statistical significance （P〈 0.05 ）. The TBIL, DBIL and IBIL levels in CA group were all lower than that of the healthy control group, and the differences all had statistical significance （Pall〈 0.05 ）. The blood UA level of multiple vessel lesion group was higher than that of single vessel lesion group, and the difference had statistical significance （P〈 0.05 ）. The TBIL and IBIL levels of multiple vessel lesion group were all higher than that of single vessel lesion group, and the differences all had statistical significance （Pall〈 0.05 ）, but there was no statistical significance in the dif- ference of DBIL level between the two groups （P〉 0.05 ）. There were correlation between narrow degree of coronary artery and blood UA, TBIL, DBIL and IBIL levels, and the correlation coefficient r were 0.907, - 0.884, -0.867 and -0.859, respectively （Pall〈 0.05）. Conclusion High blood UA and low blood bilirubin levels are the risk factors of the CA, and they can be used as the auxiliary diagnostic indicator.