摘要
目的探讨复方丹参注射液联合头孢哌酮舒巴坦钠治疗慢性肾盂肾炎(CPN)的临床疗效及对患者血清转化生子因子β1(TFG-β1)的影响。方法 110例符合纳入标准的CPN患者随机分为两组。每组各55例。对照组给予头孢哌酮舒巴坦钠治疗,观察组在对照组的基础上联合应用复方丹参注射液治疗,观察比较两组患者临床疗效、复发率、肾功能、血清TGF-β1水平及不良反应发生情况。结果观察组的总有效率和复发率分别为92.7%和1.8%,对照组的分别为78.2%和14.5%,与对照组相比,观察组的总有效率明显增高,而复发率明显降低,差异有统计学意义(P均<0.05)。治疗后,观察组肾功能指标血肌酐(Scr)、尿素氮(BUN)、尿微量白蛋白及血清TGF-β1水平较对照组均明显下降,差异有统计学意义(P均<0.05)。观察组的不良反应总发生率为9.1%,对照组为16.4%,两组不良反应发生率无统计学差异(P>0.05)。结论复方丹参注射液联合头孢哌酮舒巴坦钠治疗治疗CPN疗效可靠,可以有效提高治疗有效率,减少疾病复发,并明显改善肾功能,延缓肾脏纤维化,且不良反应少,值得临床上进一步研究。
Objective To investigate the clinical effect of compound danshen injection in combination with cefoperazone sulbactam sodium and its effects on serum transforming growth factor beta 1(TGF - β1)in treating patients with chronic pyelonephritis(CPN). Methods 110 ca-ses of CPN meeting the inclusion criteria were randomly divided into 2 groups equally. The control group was treated with cefoperazone sulbactam sodium and the observation group was treated with compound danshen injection in combination with cefoperazone sulbactam sodium. Then,the cur-ative efficacy,recurrence rate,renal function,serum TGF - β1 and adverse reactions were observed and compared. Results The observation group had a total therapeutic efficiency ratio of 92. 7% and a recurrence rate of 1. 8% ,which was respectively statistically higher and lower than that of 78. 2% and 14. 5% in the control group(both P 〈 0. 05). Compared with the control group,indices reflecting renal function of Scr, BUN,urinary albumin and serum TGF - β1 in the observation group were statistically lower after the treatment(all P 〈 0. 05). As to adverse re-action,the two groups were statistically same with the occurrence rate of 9. 1% vs 16. 4%( P ﹥ 0. 05). Conclusion Combined treatment of danshen compound injection in combination with cefoperazone sulbactam sodium for CPN was effective,which could increase the therapeutic effi-ciency ratio,reduce recurrence rate,significantly improve renal function,and delay renal fibrosis with little adverse reactions.
出处
《临床和实验医学杂志》
2015年第2期117-120,共4页
Journal of Clinical and Experimental Medicine
关键词
慢性肾盂肾炎
复方丹参注射液
头孢哌酮舒巴坦钠
转化生长因子Β1
Chronic pyelonephritis
Compound danshen injection
Cefoperazone sulbactam sodium
Transforming growth factor beta 1