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MSCs对急性肾损伤治疗的新认知及进展 被引量：1

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摘要 急性肾损伤（AKI）已逐渐成为影响公众健康的社会问题,且患病率和死亡率不断升高.间充质干细胞（MSCs）对炎性组织及损伤组织有治疗作用,且无明显副作用及并发症,可作为治疗急性肾损伤的新选择.MSCs通过向损伤肾组织“归巢”,分泌细胞因子、生长因子、趋化因子、表达酶类等,参与细胞调控,释放干细胞源性微泡（MVs）等发挥肾脏保护作用.本文主要描述了MSCs发挥肾脏保护功能的6种不同机制,重点介绍了影响MSCs“归巢”、存活及效率的因素.目前的临床研究甚少,且主要涉及MSCs对肾移植后免疫抑制的治疗,与急性肾损伤相关的数据较少;但MSCs仍可能是治疗急性肾损伤的一种创新、有效、费用低廉的方法.后期需要更多与MSCs治疗急性肾损伤相关的综合性研究,以确保下一步临床应用的安全性和有效性.
作者 向杨 白志明
机构地区 中南大学湘雅医学院附属海口医院
出处 《国际泌尿系统杂志》 2015年第1期130-134,共5页 International Journal of Urology and Nephrology
基金 海南省海口市重点科技计划项目海科工信[2010]325号
关键词 肾疾病 间质干细胞
分类号 R692 [医药卫生—泌尿科学]
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共引文献18

同被引文献13

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国际泌尿系统杂志
2015年 第1期

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