哮喘缓解期儿童呼出气一氧化氮水平与肺功能的相关性研究及临床意义

The correlation between lung function and fractionlal exhaled nitric oxide levels about children with asthma in clinical remission

目的探讨处于临床缓解期哮喘儿童呼出气一氧化氮（FeNO）水平与肺功能的相关性。方法选取2012年1月至2012年11月于成都市妇女儿童中心医院哮喘门诊就诊的处于稳定期的哮喘患儿267例为研究对象，分别测定其FeNO水平和肺功能，分析FeNO水平和肺功能的相关性。结果处于哮喘缓解期男性儿童与女性儿童FeNO值差异无统计学差异（P〉0．05）。FeNO与身高、体重、年龄呈正相关（r=0．213、0．147、0．276，P=0．001、0．025、0．000）。与FEF25％、FEF50％、FEF75％各占预计值呈负相关（r=-0．147、-0．127、-0．127、P=0．0017、0．04、0．04）。结论FeNO水平与肺功能对临床缓解期哮喘儿童小气道的监测有一定的相关性，可将FeNO纳入哮喘管理的一个监测指标。

Objective To study the correlation between the fractionlal exhaled nitric oxide （FeNO） levels and the lung function about children with asthma in clinical remission. Methods Selecting 267 cases as the research object, come from Cheng Du Women and Children Hospital, measure their FeNO levels and pulmo- nary function,analysis the correlation the FeNO level with the lung function. Results There is no statistical difference about FeNO between male and female children in asthma remission. FeNO has positive correiation with heigh, weight, age （ r = 0.213,0.147,0. 276 ; P = 0.001,0. 025,0. 000 ） and negative correlation with pred % of FEF25 %, FEF50 % , FEF75 % （ r = - 0. 147, - 0. 127, - 0. 127 ; P = 0. 001 7,0.04,0.04 ）. Conclusion FeNO levels and lung function of clinical remission of asthma children has correlation in small airway monitoring, FeNO should be incorporated into a monitoring indicator of asthma management.