摘要
β细胞衰竭是2型糖尿病发病的重要机制.自噬是一种细胞内的代谢降解过程,能够有效地降解胞内聚集的蛋白和损伤的细胞器.研究显示,抑制自噬会导致胰岛素分泌减少及高血糖.而刺激自噬则可以改善糖尿病、增加胰岛素分泌、防止β细胞凋亡.这些结果提示：自噬在维持内环境稳定,保护胰岛β细胞的结构和功能等方面发挥重要作用.除此之外,自噬在缓解胰岛素抵抗状态下的应激反应过程中也发挥重要作用.自噬功能的损伤会使个体更易于患2型糖尿病.
β cell failure is crucial in the onset of type 2 diabetes mellitus.Autophagy is a cellular degradation-recycling process for aggregated proteins and damaged organelles.Inhibition of autophagy causes insulin deficiency and hyperglycemia.Autophagy deficient mice shows degenerated β-cell and impaired glucose tolerance with reduced insulin secretion.Stimulating autophagy can improve diabetes,increase pancreatic insulin content,and prevent β-cell apoptosis.These results suggest that autophagy plays an important role in maintaining internal environmental stabilization,protecting architecture and function of islet β cells.Autophagy also serves as a crucial element of stress response under insulin-resistant states.Impairment of autophagic function could thus predispose individuals to type 2 diabetes mellitus.
出处
《国际内分泌代谢杂志》
2015年第1期53-55,共3页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目（81270861）
关键词
自噬
2型糖尿病
胰岛Β细胞
Autophagy
Type 2 diabetes mellitus
Islet beta cells
