老年男性高血压患者夜间脉压指数与血清25羟维生素D_3水平的关系

Relation between nocturnal pulse pressure index and serum 25-hydroxy vitamin D_3 level in elderly male hypertensive patients

目的探讨血清25羟维生素D3与老年男性高血压患者夜间脉压指数(pulse pressure index,PPI)的相关性。方法选择老年男性高血压患者471例,根据动态血压监测结果计算夜间PPI,按夜间PPI水平分为2组:低水平组(241例)PPI<0.46,高水平组(230例)PPI≥0.46,测量身高、体质量,计算体质量指数(body mass index,BMI),并检测空腹血糖、血脂、糖化血红蛋白、肌酐、血钙和血磷等指标,采用酶联免疫法测定血清25羟维生素D3水平,比较2组各指标及夜间PPI的差异。结果 2组患者TC、TG、LDL-C、HDL-C、糖化血红蛋白、空腹血糖、肌酐、血钙、血磷及降压药治疗比较,差异无统计学意义(P>0.05)。低水平组患者25羟维生素D3水平显著高于高水平组[(38.47±20.20)nmol/Lvs(34.18±12.78)nmol/L],差异有统计学意义(P=0.006)。与低水平组比较,高水平组25羟维生素D3水平缺乏显著增加,差异有统计学意义(P<0.05)。多因素logistic回归分析显示,夜间PPI与25羟维生素D3和年龄独立相关。结论在老年男性高血压患者中,低水平血清25羟维生素D3可能是PPI增高的独立危险因素。

Objctive To study the relation between nocturnal pulse pressure index （PPI） and serum 25-hydroxy vitamin D3 level in elderly male hypertensive patients.Methods Four hundred and seventy-one elderly male hypertensive patients were divided into PPI〈0.46 group （n=241） and PPI≥0.46 group （n=230）.Their body height and BMI were measured.Their plasma levels of fasting blood glucose,lipid,H bA1 C,creatinine,calcium,and phosphorus were tested.Their serum 25-hydroxy vitamin D3 level was measured by ELISA.Differences in the above parameters and nocturnal PPI were compared between the two groups.Results The serum 25-hydroxy vitamin D3 level was significantly higher in PPI〈0.46 group than in PPI≥0.46 group （38.47±20.20 nmol/L vs 34.18 ± 12.78 nmol/L,P =0.006）.Multivariate logistic regression analysis showed that nocturnal PPI was independently related with serum 25-hydroxy vitamin D3 level and age.Conclusion Low serum 25-hydroxy vitamin D3 level is an independent risk factor for high nocturnal PPI in elderly male hypertensive patients.