摘要
目的 探讨血清25羟维生素D3与老年患者冠状动脉狭窄程度相关性.方法 对269例老年患者行冠状动脉造影术,分为狭窄组114例和正常组1 55例,应用Gensini积分判断冠状动脉狭窄程度.测定血清25羟维生素D3水平,按照25羟维生素D3四分位数分为：Q1组（＜15.0 nmol/L）60例,Q2组（15.0～22.1 nmol/L）74例,Q3组（22.2～35.6 nmol/L）68例,Q4组（＞35.6 nmol/L）67例.结果 狭窄组与正常组25羟维生素D3比较,差异有统计学意义[（25.05±16.08）nmol/L vs （31.83±22.36）nmol/L,P=0.004];Q1组、Q2组、Q3组与Q4组Gensini 积分比较,差异有统计学意义（P＜0.05,P＜0.01）.血清25羟维生素D3与C反应蛋白呈负相关（r=0.548,P=0.000）,与Gensini评分呈负相关（r=-0.183,P=0.003）.多元logistic回归分析显示,血清25羟维生素D3是老年患者冠状动脉狭窄独立保护因素（P＜0.01）.结论 低水平25羟维生素D3与老年患者冠状动脉狭窄程度相关,需进一步研究证实补充25羟维生素D3是否会减少老年冠心病的发病.
Objective To study the assoiation between serum 25 hydroxy vitamin [25（OH）D3] level and coronary artery stenosis in elderly patients.Methods Two hundred and sixty-nine elderly patients who underwent coronary angiography were divided into stenosis group （n=114） and control group （n=155）.Their serum [25（OH）D3] level was measured and coronary stenosis was assessed according to their Gensini score.The patients were further divided into Q1〈 15 nmol/L group （n=60）,Q2：15-22.125 nmol/I group （n=74）,Q3：22.126-35.6 nmol/L group （n=68）,and Q4〉35.6 nmol/L group （n =67）.Results The serum[25（OH）D3] level was significantly higher in stenosis group than in control group （P=0.004）.The Gensini score was significantly higher in Q1,Q2,and Q3 groups than in Q4 group （P〈0.05） and decreased with the increasing serum [25（OH）D3] level （r=-0.183,P=0.003）.The serum [25（OH）D3] level was negatively related with the CRP level （r =-0.548,P =0.000） and the Gensini score （r =-0.183,P=0.003）.Multivariate logistic regression analysis showed that serum [25 （OH） D3] level was an independent protective factor for coronary artery stenosis in elderly patients （P〈 0.01）.Conclusion Low serum [25（OH）D3] level is related with coronary artery stenosis in elderly patients.Further study is thus needed to determine whether [25（OH）D3] can reduce the incidence of coronary heart disease in elderly patients.
出处
《中华老年心脑血管病杂志》
CAS
2015年第1期45-48,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
国家自然科学基金(81160039)
