中老年人骨代谢生化标志物骨钙素测定临床价值分析

Analysis of clinical values in measuring osteocalcin （biochemical markers）of elderly people in bone metabolism

目的：探讨中老年人骨代谢生化标志物骨钙素（BGP）测定临床价值．方法：将1500例社区老年居民按年龄分组（每间隔10岁为一组），测定并比较不同性别和年龄组参与人员的血清BGP、碱性磷酸酶和磷含量．结果：不同性别组血清BGP含量随年龄的增加而降低，二者之间呈负相关，但是女性50～59年龄组血清BGP含量显著高于另外两年龄组（P＜0．05）；不同性别组的血清碱性磷酸酶和磷含量之间无显著性统计学差异（P＞0．05）．结论：血清BGP是老年人骨代谢指标的生物标志物，具有较高的敏感性和特异性，检测血清BGP水平可用于中老年人的骨折风险评估．

AIM：To explore clinical value of osteocalcin （biochemical markers ） in bone metabolism in elderly people. METHODS：1500 cases of elderly residents were divided by age （every 10 years as a group ）, and determine and compare participants＇ content of BGP,ALP and P according to the different gender and age.RESULTS：The serum BGP levels decreased with increasing of age in different gender groups and there were negative correlation,but the serum BGP levels of women in 50～59 age group were significantly higher than the other two groups （P〈0.05）.There was no difference in serum ALP and P levels between different groups （P〉0.05 ）.CONCLUSION：Serum BGP is the bone metabolism biomarkers with higher sensitivity and specificity,and we can assess the risk of fracture in the elderly people with measuring serum BGP levels.