儿童代谢综合征血清瘦素水平变化及其临床意义

The changes and significance of leptin in serum of metabolic syndrome in children

目的探讨代谢综合征血清瘦素变化及其临床意义。方法回顾性分析本院生长发育门诊就诊儿童,MS组35例,SO组35例,对照组35例。对3组血清瘦素(leptin,Lep)水平进行检测,并与血生化指标和体质指数进行相关性分析。结果 MS组Lep为(11 337.36±1 074.98)ng/L,SO组Lep为(5 536.44±291.21)ng/L,对照组Lep为(3 395.42±113.05)ng/L;SO组和对照组差异有统计学意义(t=40.55,P<0.01),MS组与对照组差异有统计学意义(t=43.47,P<0.01),MS组和SO组差异有统计学意义(t=9.71,P<0.01);血清Lep与BMI呈正相关(r=0.71,P<0.01),与血糖、甘油三酯、总胆固醇、低密度脂蛋白呈正相关(r=0.93;r=0.76;r=0.91;r=0.67,P<0.01),与高密度脂蛋白呈明显负相关(r=-0.76,P<0.01)。结论血清Lep水平可反应儿童MS病情及进展。

Objective To investigate the level changes and significance of leptin in serum of metabolic syndrome in children.Methods Retrospectively analyzed outpatients who visited the growth and development department in our hospital. 35 cases in metabolic syndrome（ MS） group,35 cases in simple obesity（ SO） group,and 35 cases in the healthy group. Then the levels of leptin in serum were detected and the correlation analysis of blood biochemical indexes and constitutional index were performed.Results The level of leptin were（ 11 337. 36 ± 1074. 98） ng / L in metabolic syndrome group,and（ 5 536. 44 ± 291. 21） ng / L simple obesity group respectively,and（ 3 395. 42 ± 113. 05） ng / L in the healthy group. Compared with the serum leptin levels,there was significantly difference between the healthy group and obesity group（ t = 40. 55,P 〈0. 01）; also between the healthy group and syndrome group（ t = 43. 47,P 〈0. 01）,there was significantly difference between the simple obesity group and metabolic syndrome group（ t = 9. 71,P 〈0. 01）; the concentration of serum leptin was positively correlated with body mass index（ r = 0. 71,P 〈0. 01）,and the concentration of serum leptin was positively correlated with fasting blood glucose,total cholesterol,triglyceride,low density lipoprotein（ r = 0. 93,r = 0. 76,r = 0. 91,r = 0. 67,P 〈0. 01）,and the serum leptin was negatively correlated with high density lipoprotein（ r =-0. 76,P 〈0. 01）. Conclusion The serum level of leptin can reflect the condition and progress of metabolic syndrome in children.