2013年无锡市流感病毒流行特征与人群流感抗体水平分析

Analysis on influenza virus epidemic characteristics and population antibody level of influenza in Wuxi in 2013

目的了解无锡市2013年流感流行特征与人群流感病毒抗体状况,为流感预防控制提供科学依据。方法对2013年无锡市哨点医院送检的流感样病例,应用荧光PCR鉴定流感病毒型/亚型。采用红细胞凝集抑制实验对血清标本进行季H1、季H3、新H1(2009)、BV和BY亚型抗体检测。结果 2013年共收到哨点医院送检流感样病例1 827份,核酸阳性124份,阳性率为6.79%。124例阳性病例中,男性患者为69例,女性患者为55例,男、女性别流感病毒感染率差异无统计学意义(χ2=1.424,P=0.233),不同年龄组之间的差异有统计学意义(χ2=66.226,P<0.05)。人群流感抗体分析,不管是健康人群还是患者,都是季H3抗体阳性率最高。结论 2013年无锡市主要以季H3和新H1(2009)流行为主,2种毒株几乎全年都有流行。这2种毒株在人群中的免疫屏障已经形成,预计在下一个流行季不会引起大的流行。

Objective To investigate the epidemic characteristics and antibody status of influenza virus in Wuxi in 2013,and to provide scientific basis for prevention and control of influenza virus. Methods By using fluorescence PCR samples provided from sentinel hospitals in Wuxi in 2013 were used in the detection of influenza virustype or subtype. Application of hemagglutination inhibition test was used to detect antibodies of H1,H3,H1（ 2009）,BV,and BY hypotype. Results Received 1 827 copies of influenza like cases from sentinel hospitals in 2013. Among them,nucleic acid positive is 124,the positive rate was6. 79%. The 124 positive cases,69 cases were male patients and 55 cases were female patients. Between male and female there is no statistical significance（ χ^2= 1. 424,P = 0. 233）,but there is differences in influenza virus infection in each age group（ χ^2= 66. 226,P 〈0. 05）. Analysis of population antibody in influenza virus showed,whether for the general healthy population or patients in sentinel hospitals the highest positive rate was of H3. Conclusion Mainly in H3 and H1（ 2009）,two strains almost are popular year-round in Wuxi in 2013. The antibody immune barrier of two strains has been formed in the crowd,and expectation tells it wounld not cause a pandemic in the next season.