基于聚磷腈可降解电活性材料的合成及其降解行为研究

Synthesis and degradation behavior study of biodegradable electroactive materials based on polyphosphazene

以六氯环三磷腈为原料,加热开环聚合制备了聚二氯磷腈,再分别以苯胺五聚体为功能单元、甘氨酸乙酯和赖氨酸为调节基团,通过两步亲核取代反应,合成了两种可用于神经支架工程材料的可降解电活性高分子聚[(甘氨酸乙酯/苯胺五聚体)磷腈](PGAP)和聚[(赖氨酸/苯胺五聚体)磷腈](PLAP)。通过红外、热重、核磁、循环伏安、紫外等对聚合物进行了全面的表征。在此基础上,重点研究了氨基酸类侧链取代基对聚磷腈降解行为的影响。研究结果表明,侧链氨基酸类取代基的类型和比例对此高分子材料的降解行为有着关键性影响。其降解速率随着取代基比例的增加而加快,此外,随着氨基酸侧链基团极性的增加,降解速率增加。

Using hexachlorocyclohexane three phosphazene as raw material,polydichlorophosphazene was pre-pared by ring-opening polymerization.Then using aniline pentamer as functional unit,lysine and glycine ethyl ester as adj usting units,two electro-active biodegradable polymers of poly [（glycine ethyl ester/aniline pen-tamer）phosphazene]（PGAP）and poly [（lysine/aniline pentamer）phosphazene]（PLAP）were synthesized. Structure and electro-active property of the polymers were characterized by IR,TG,1 H NMR,UV and cyclic voltammetry.On this basis,influences of mass ratio and polarity of substituted side group on degradation of the polymers were studied.The experimental results show that,the side adj usting units had a critical impact on the degradation behavior of these polymers.The degradation rate will augment with increasing the proportion and polarity of amino acid derivative group.