喷砂酸蚀处理促进Ti6Al7Nb表面钙磷沉积

Deposition of Ca and P enhanced on the surface of Ti6Al7Nb by SLA

研究了Ti、Ti6Al4V和Ti6Al7Nb 3种钛基材料在喷砂酸蚀处理后成骨细胞在其表面生长的生物活性。通过Al2O3喷砂和盐酸、硫酸混合物酸蚀的表面改性方法,在Ti、Ti6Al4V和Ti6Al7Nb3种钛基材料表面进行喷砂酸蚀处理,通过SEM观察样品的表面形貌,样品的表面呈现出微米级多孔形貌;将样品浸入模拟体液(simulated body fluid,SBF)中浸泡7,14和21 d后通过SEM、X射线衍射仪(XRD)分析样品表面沉积物的形貌、物相,样品浸入SBF 14 d后,Ti6Al7Nb表面最先观察到表面覆盖的羟基磷灰石涂层;样品浸入SBF 21 d后,Ti、Ti6Al4V和Ti6Al7Nb表面都观察到羟基磷灰石涂层。羟基磷灰石涂层有利于促进钛基植入体与体内骨组织的骨结合,喷砂酸蚀处理的Ti6Al7Nb表现出良好的生物活性。

Titanium （Ti）and its alloys have been used widely as implants due to their excellent mechanical toughness,strength,corrosion resistance and biocompatibility.However,they exhibit poor osteoinductive properties because of their bioinert character.To improve their bioactivity,numerous techniques have been e-laborated to enhance the surface compatibility of implants with bone.Ti and Ti6Al4V are mostly used in the aerospace,occupied 50% of the titanium market.However,Ti has low strength and undergoes physical abra-sion due to oral prophylaxis and other processes in oral cavity.Furthermore,the grey color of Ti can cause aes-thetic problems when it is inadequately masked by soft tissue at gingival area.Ti6Al4V began to lose its popu-larity after recognition of toxicity arising from in-vivo release of vanadium present in the composition.To over-come these drawbacks,Ti6Al7Nb alloy has been developed specifically for implant applications by substitution of vanadium with niobium.In the present study,the in-vitro biological responses to Ti,Ti6Al4V and Ti6Al7Nb were investigated after modifying their surfaces by sandblasting and acid etching （SLA）.The SLA process was sandblasted by Al2 O 3 particles and acid etched by a mixture of hydrochloric acid and sulfuric acid.After the process,the surfaces of the samples were porous of micro meters.Simulated body fluid （SBF）tests were con-ducted to compare the biological performance of the samples.The sample surface morphologies were character-ized by SEM,surface crystal structure of the samples was analyzed by using an X-ray diffractometer （XRD）. Even though micro structure of the samples exhibited somewhat similar,the deposition of calcium （Ca）,and phosphate （P）on the surface of Ti6Al7Nb alloy was faster and greater than that of the Ti and Ti6Al4V,which is significant for implant surface activity.