人附睾蛋白4和细胞角蛋白19片段联合检测在非小细胞肺癌辅助诊断中的意义

Significance on the combined detection of human epididymis protein 4 and CYFRA21-1 in the diagnosis of non-small cell lung cancer

目的探讨人附睾蛋白4(HE4)和细胞角蛋白19片段(CYFRA21-1)联合检测在非小细胞肺癌(NSCLC)辅助诊断中的意义。方法采用电化学发光法分别检测50例NSCLC患者、40例肺炎患者和50名健康体检者血清HE4、CYFRA21-1水平,通过受试者工作特征(ROC)曲线评价2项指标联合检测对NSCLC辅助诊断的价值。结果肺癌患者整体CYFRA21-1、HE4水平及Ⅰ~Ⅱ期肺癌患者HE4水平显著高于肺炎患者及健康体检者(P【0.05)。Ⅲ~Ⅳ期NSCLC患者HE4及CYFRA21-1水平高于Ⅰ~Ⅱ期NSCLC患者(P【0.05)。经ROC曲线分析,HE4和CYFRA21-1联合检测的敏感性显著高于任一单项检测的敏感性。结论血清HE4检测比CYFRA21-1对于NSCLC有更高的早期诊断价值。联合检测HE4和CYFRA21-1对诊断NSCLC有较高的敏感性,适用于临床的肺癌普查。

Objective To investigate the significance on the combined detection of human epididymis protein 4( HE4) and cytokeratin 19 fragment( CYFRA21-1) in the diagnosis of non-small cell lung cancer( NSCLC). Methods The levels of serum HE4 and CYFRA21-1 were detected in 50 NSCLC patients,40 patients with pneumonia and 50 healthy subjects. The diagnosis significance of the combined detection of serum HE4 and CYFRA21-1 for NSCLC was analyzed by receiver operating characteristic( ROC) curve. Results The levels of serum CYFRA21-1 and HE4 in all the NSCLC patients and the level of HE4 in patients with Ⅰ-Ⅱ stages of NSCLC were significantly higher than those in pneumonia patients and healthy subjects( P < 0. 05). The levels of serum HE4 and CYFRA21-1 in patients with Ⅲ-Ⅳstages of NSCLC were significantly higher than those in patients with Ⅰ-Ⅱ stages of NSCLC( P < 0. 05). The sensitivity of the combined detection was high than that of any single detection. Conclusions The detection of serum HE4 has a high significance for the early diagnosis of NSCLC compared with CYFRA21-1 detection. The combined detection of HE4 and CYFRA21-1 for the diagnosis of NSCLC has a high sensitivity,and is suitable for the clinical screening of lung cancer.