钴铬合金烤瓷冠修复对不同年龄组患者龈沟液成分的影响

Effects of metal ceramic crown on gingival crevicular fluid in patients with different ages

目的:探讨不同年龄组患者烤瓷冠修复后龈沟液成分的变化情况。方法:选择2012年4月至2014年1月在解放军总医院口腔科就诊,需进行烤瓷单冠修复的患者100名作为受试对象,其中男、女性各50名,年龄20-59岁,按年龄段分成20-29岁组,30-39岁组,40-49岁组,50-59岁组,每组25名。采用钴铬合金烤瓷单冠进行修复,分别在修复前及修复后1个月检测基牙龈沟液的分泌量以及白细胞介素-1β(interleukin-1β,IL-1β),白细胞介素-6(inter leuk in-6,IL-6)和肿瘤坏死因子-α水平(tumor necr osis factor-α,TNF-α)。结果:修复后1个月基牙龈沟液分泌量以及白细胞介素1,白细胞介素6和肿瘤坏死因子α水平高于修复前。但随着年龄增加,龈沟液分泌量及炎性因子升高的量越少。龈沟液分泌量,在20-29岁组,30-39岁组治疗后显著高于治疗前,在40-49岁组,50-59岁组治疗前后差异无统计学意义。白细胞介素1β,各组治疗后1个月均显著高于治疗前。白细胞介素6,各组治疗后1个月均显著高于治疗前。肿瘤坏死因子,在20-29岁组,30-39岁,40-49岁组治疗后显著高于治疗前,在50-59岁组治疗前后差异无统计学意义。结论:钴铬合金烤瓷单冠修复可使各年龄组患者龈沟液分泌量增加,相关炎性因子表达增高。但年龄越大,升高的量越少。

Objective： To investigate the ingredient changes of gingival crevicular fluid after metal ceramic restoration in patients with different ages. Methods： 100 patients （50 male and 50 female, 20-59 years old） indicated for metal ceramic restoration in our department in the past two years were recruited. The patients were divided into four groups （25 patients per group） by age： 20-29, 30-39, 40-49, and 50-59 years old. After routine periodontal prophylaxes, single cobalt-chromium alloy ceramic crowns were restored on each patient. Gross secretory volume of GCF, IL-1, IL-6 and TNF-α levels were measured before restoration and one month after restoration. Result： Compared to those before restoration, the gross secre- tory volume of GCF, IL-1, IL-6 and TNF-α levels significantly increased 1 month after restoration, while the degree of in- crease was inversely proportional to age. The gross secretory volumes （mg/sample） of GCF in the four groups of 20-29, 30-39, 40-49, and 50-59 years old before and after restoration were 0.291 ± 0.023 VS 0.458± 0.057, 0.248 ± 0.031 VS 0.344± 0.048, 0.231± 0.039 VS 0.286± 0.033, 0.267± 0.029 VS 0.277± 0.038; the amount of IL-1 β（μg/L）： 7.66± 1.04 VS 18.38± 3.17, 8.35± 1.21 VS 16.85± 2.27, 7.84± 0.95 VS 14.36± 2.86, 8.03± 1.14 VS 13.36± 2.31; the amount of IL-6（ng/L）： 27.82± 3.54 VS 66.48± 7.36, 30.74± 2.79 VS 62.47± 6.93, 28.36± 3.67 VS 52.26± 5.49, 31.07± 4.42 VS 39.15± 3.42; the amount of TNF-α （μg/L）： 1,12 ± 0.15 VS 2.04 ± 0.26, 1.26 ± 0.20 VS 2.11 ± 0.19, 0.96±0.22 VS 2.24 ± 0.31, 1.06 4- 0.28 VS 1.48± 0.44. Conclusion： Cobalt-chromium alloy ceramic restorations could cause an increase of GCF secretion, and IL-1, IL-6 and TNF-α levels in GCF in the patients with different ages. The degree of increase is inversely proportional to age.