肝郁证在乳腺癌中的研究进展

Study Development of Liver Depression Syndrome in Breast Cancer

乳腺癌是全球女性最常见的肿瘤,近20年里,我国乳腺癌的发病率及死亡率均呈上升趋势,现已位居我国女性恶性肿瘤发病谱之首。中医对乳腺癌的病因病机早有认识,古今各大医家对乳腺癌的辨证治疗也有独到见解,而肝郁始终被认为是乳腺癌病因病机的关键,也是辨证施治的要点。这不仅说明了肝郁证在乳腺癌中的重要地位,也为临床治疗提供思路。随着现代医学的发展,实验研究和临床研究均发现肝郁证与乳腺癌密切相关。因此,进一步研究肝郁证在乳腺癌发生发展过程中的作用机制不仅可能有助于筛查乳腺癌高危人群,提高早期诊断率,也有能助于寻找新的药物靶标。

Breast cancer （BC） is the most common cancer of women worldwide. Over the past 20 years, the incidence and mortality rates of BC have increased and have ranked the first place of the female cancer in our country. In the theory of traditional Chinese medicine （TCM）, etiology and pathogenesis of BC have long been recognized. Base on these basic theories, TCM physicians have developed their typical opinions on BC treatment. Liver depression has been considered as the key point and the main syndrome type in BC syndrome differentiation. It showed the impor-tance of liver depression syndrome in breast cancer and provided ideas for clinical treatment. With the development of modern science, several experimental and clinical studies have found that liver depression syndrome is closely related to BC. Further study on liver depression syndrome in BC procession may not only helpful to screen high-risk BC groups and improve the early diagnosis rate but also helpful to find new drug targets.