静注氟比洛芬酯预防肺叶手术中全麻患者苏醒期躁动的临床研究

The Clinical Research of Intravenous Injection of Flurbiprofen Ester on the Prevention of Emergence Agitation after General Anesthesia in Lung Surgery

目的:探讨肺叶手术中超前应用氟比洛芬酯对减轻全身麻醉苏醒期躁动发生率的影响。方法:60例肺叶切除术患者随机分为A组和B组,每组30例,两组均常规诱导全麻气管插管,术中瑞芬、丙泊酚、维库溴铵泵住维持麻醉,A组于术前给予氟比洛芬酯1 MG/KG。比较两组躁动得分、苏醒后(10 min、30 min、1 h、2 h、4 h、24 h)六个时间点疼痛评分及不良反应发生率。结果:两组出血时间、拔管时间、麻醉时间差异均无统计学意义(均P>0.05);A组患者的躁动得分显著低于B组,差异有统计学意义(P<0.05);两组的VAS评分差异有统计学意义(P<0.05),不同时间点的VAS评分差异有统计学意义(P<0.05),分组与时间之间存在交互作用(P<0.05);A组患者的不良反应发生率低于B组,差异有统计学意义(P<0.05)。结论:肺叶手术中超前应用氟比洛芬酯具有良好的镇痛效果,可以降低全身麻醉苏醒期躁动的发生率。

Objective： To expore the effect of flurbiprofen ester preemptively used in lung surgery on reducing the incidence of emergence agitation after general anesthesia. Methods： 60 lobectomy patients were randomly divided into two groups with 30 cases in each group. General anesthesia and tracheal intubation were inducted commonly to all patients in the two goups： remifentanil, propofol and vecuronium bromide were pumped to make anesthesia maintain. In addition, 1MG/KG flurbiprofen ester was given to group A before the lung surgery. Agitation score, visual analogue scale after revival（10 min, 30 min, 1 h, 2 h, 4 h, 24 h） and incidence of adverse reactions were compared between two groups. Results： The bleeding duration, extubation time and anesthesia time between two groups showed no significant statistical differences（P〉0.05）, while the agitation score of group A was lower than that of group B（P〈0.05）, visual analogue scale between two groups presented significant statistical differences（P〈0.05）, visual analogue scale at different time points had significant statistical differences（P〈0.05）, there was interaction between groups and time（P〈0.05）; The incidence of adverse reactions of group A was lower than that of group B（P〈0.05）. Conclusions： Application of flurbiprofen ester before lung surgery has good effect of analgesia, and it can reduce the incidence of emergence agitation after general anesthesia.