中药联合克罗米芬治疗排卵障碍性不孕的临床效果

The Clinical Efficacy of Combination of Traditional Chinese Medicine and Western Medicine in the Treatment of Anovulatory Infertility

目的:探讨中西医结合法治疗排卵障碍性不孕的临床效果。方法:112例排卵障碍性不孕患者随机分为观察组与对照组,每组各56例,对照组患者给予克罗米芬治疗,观察组患者在克罗米芬治疗的基础上加用补肾活血促排卵类中药内服治疗,对两组患者治疗后的妊娠率、临床疗效进行比较分析。结果:观察组患者治疗后妊娠率为62.5%,高于对照组患者(41.1%),总有效率为89.3%,高于对照组患者(73.2%),差异有统计学意义(P<0.05)。观察组患者治疗后的中医症候积分、FSH、LH、雌二醇水平均高于对照组,子宫内膜厚度及优势卵泡直径均大于对照组,差异均有统计学意义(P<0.05)。结论:菟丝子、全当归等组成的补肾活血方剂能明显改善排卵障碍性不孕患者的临床表现及中医证候积分,调节不孕患者FSH、LH、雌二醇、睾酮水平,促进子宫内膜生长及卵泡的发育,提高妊娠率。

Objective： To explore the clinical efficacy of combination of traditional Chinese medicine and Western medicine in the treatment of anovulatory infertility. Methods： 112 patients of anovulatory infertility were randomly divided into the observation group and the control group, each group with 56 cases. The patients in the control group were treated with clomiphene while the patients in the observation group were treated with Chinese traditional medicine on basis of clomiphene. The clinical curative effect of the two groups was compared. Results： The pregnancy rate in the observation group was 62.5%, higher than that of the control group（41.1%） and the total effective rate in the observation group was 89.3%, higher than that in the control group（73.2%）. The levels of symptom integral,FSH, LH, estradiol in the observation group were higher than those in the control group, and the endometrial thickness, dominant follicle diameter were greater than those of the control group（P〈 0.05）. Conclusion： The Chinese traditional medicine, such as tusizi and quandanggui, can significantly improve the treatment efficacy in patients with anovulatory infertility. It can increase the levels of FSH,LH, estradiol and testosterone, promote the growth of endometrium and ovarian follicles development, and increase the pregnancy rate.