血压、血脂、血糖、同型半胱氨酸及超敏C反应蛋白水平与脑梗死发病危险性的关系

Relation of Cerebral Infarction with Blood Pressure, Blood Lipids, Blood Glucose, Homocysteine and hs-C-reactive Protein Levels

目的:探讨血压、血脂、血糖、糖化血红蛋白、同型半胱氨酸(HCY)和超敏C反应蛋白(hs-CRP)与脑梗死发病危险性的相关性,为及时防止脑梗死的发病及早期诊断脑梗死提供理论依据。方法:采用回顾性病例对照研究,用全自动生化分析仪器检测各项生化指标,并运用SPSS 20.0软件包对256例脑梗死患者和216例健康对照者的血生化指标进行统计分析。同时,将脑梗死组分为三组:单纯脑梗死组、合并高血压组、合并糖尿病组,分别与正常对照组进行血脂水平的分析比较。结果:血压、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇酯(HDL-C)、同型半胱氨酸(HCY)、血糖、hs-CRP水平和总胆固醇/高密度脂蛋白胆固醇(TC/HDL-C)比值在病例组和对照组间有显著性差异(P<0.05)。同时,在三组不同的病例组中血脂(TC、TG、LDL-C、TC/HDL-C)水平和HCY水平明显高于正常对照组,而HDL-C水平则明显低于对照组。(P<0.05)。结论:高血压、高血糖、HCY、hs-CRP水平增高及血脂异常均与脑梗死发病危险性相关,联合检测上述指标对预防及治疗脑梗死均有重要意义。

Objective： To explore the relation of blood pressure, blood lipids, blood glucose, glycated hemoglobin, homocysteine（HCY） and high sensitivity-C-reactive protein（hs-CRP） and the risk of cerebral infarction, to provide theoretical basis for preventing the onset and early diagnosis of cerebral infarction. Methods： This is a retrospective case-control study with 256 cerebral infarction patients and 216 healthy controls. The automatic biochemical analyzer was used to detect the biochemical parameters of the participants and then analyzed the parameters with SPSS 20.0. In addition, the cerebral infarction group was divided into three groups： simple cerebral infarction group, the group with hypertension, the group with diabetes and the normal control group, which were compared with lipid levels, respectively. Results： There were significant differences of blood pressure, total cholesterol（TC）, triglyceride（TG）, low density lipoprotein cholesterol（LDL-C）, high density lipoprotein cholesterol（HDL-C）, homocysteine, glucose, hs-CRP levels and total cholesterol / high-density lipoprotein cholesterol（TC/HDL-C） ratio between cases and controls（P〈 0.05）. Meanwhile, lipids（TC, TG,LDL-C, TC/HDL-C） levels in three different groups of cases were significantly higher than those in the controls, however HDL-C levels were significantly lower than those in the controls（P〈 0.05）. Conclusion： High blood pressure, high HCY, high blood glucose, high hs-CRP levels and dyslipidemia were associated with the risk of cerebral infarction, detecting the above indicators have great significances for the prevention and treatment of cerebral infarction.