放化疗与介入性动脉化疗治疗局部晚期宫颈癌的临床研究

Clinical Research of Radiotherapy and Chemotherapy and Interventional Artery Chemotherapy in the Treatment of Locally Advanced Cervical Cancer

目的:比较分析放化疗与介入性动脉化疗治疗局部晚期动脉宫颈癌的临床效果。方法:选择我院局部晚期宫颈癌患者97例,依据治疗方法分为常规组(行传统放化疗)55例和介入组(行介入性动脉化疗)42例。观察治疗后肿瘤大小、近期疗效、根治性手术率、术后并发症,对生活质量指数进行评分,评价两种方法的临床效果。结果:治疗后,两组患者近期疗效比较差异无统计学意义(P>0.05);介入组肿瘤直径明显小于常规组,而根治性手术率明显高于常规组,差异均具有统计学意义(P<0.05);介入组患者日常生活、健康、总体情况以及总的评分均明显高于常规组,差异具有统计学意义(P<0.05),同时介入组并发症较少。结论:放化疗与介入性动脉化疗治疗局部晚期动脉宫颈癌近期临床疗效均较好,但介入性动脉化疗具有较高的根治性手术率以及生活质量,且并发症少。

Objective： To compare the clinical effects of radiotherapy and chemotherapy and interventional artery chemotherapy on the treatment of locally advanced cervical cancer. Methods： 97 patients with locally advanced cervical cancer in our hospital were selected and divided into the conventional group and the intervention group. 55 cases in the conventional group were treated with traditional radiotherapy and chemotherapy, while another 42 patients in the intervention group were treated with interventional artery chemotherapy. Then observed the tumor size, short-term curative effect, rate of radical operation, postoperative complications and the life quality of patients in the two groups were observed and compared. Results： There was no significant difference in short-term efficacy between the two groups（P〉 0.05）. The diameter of the tumor in the intervention group was smaller than that of the patients in the conventional group, but the rate of radical operation was significantly higher with statistically significant difference（P〈 0.05）; The scores of life quality of patients in the intervention group were higher than that of the patients in the conventional group（P〈 0.05）; The incedence of postoperative complications of patients in the intervention group was lower than that of the conventional group（P〈 0.05）. Conclusion：Both radiotherapy and chemotherapy and interventional artery chemotherapy have fairly good short-term effects in the treatment of locally advanced cervical cancer, while the interventional artery chemotherapy has high rate of radical operation and quality of life and fewer complications.