摘要
miRNA(microRNA)是一类小的非编码RNA,普遍存在于动物、植物等多个物种中,研究表明在原生生物以及病毒中也有miRNA。miRNA在生物的成长、发育、细胞凋亡、神经紊乱、癌症等多个方面都起到至关重要的作用,miRNA还可作为Biomarker应用于癌症等疾病的诊断和治疗。miRDOA(miRNA Database and Online Analysis)数据库存储了二百多个物种的miRNA相关信息,提供了基本的浏览和搜索功能。用户可以通过物种来浏览miRNA相关数据,也可以通过miRNA、靶基因或者序列进行检索。除此之外,miRDOA还提供了在线分析模块,主要对高通量测序数据进行初步分析,在此基础上,添加了靶基因预测、表达谱数据差异分析,以及在线BLAST功能。miRDOA是一个完全免费的开源的数据库网站,并实时更新。
miRNA （microRNA） is a kind of small non-coding RNAs that generally exist in animals, plants, and other species. The study shows that there are miRNAs in protozoa and viruses, miRNAs play crucial roles in many biogenesis, for example, biological growth, development, cell apoptosis, neurological disorders, cancer and other aspects, miRNAs can also be used as biomarkers in the diagnosis and treatment of diseases such as cancer, miRDOA （miRNA Database and Online Analysis） is designed to retrieve and analyze sequencing data and expression profiles of miRNAs. It provides browsing and searching function for miRNAs, targetor sequences. It also provides online analysis of High-throughputsequencing data, target prediction, expression profiles analysis and online BLAST. miRDOA will be updated over time and is free available for non-commercial use atmirdoa. biocloud, org. cn.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2014年第11期1-8,共8页
China Biotechnology
基金
北京市科学研究院萌芽项目
