左卡尼汀对维持性血透患者营养状况及血脂的影响

The effects of levocarnitine on nutritional status and blood lipid in hemodialysis patients

目的:研究左卡尼汀(左旋肉碱)改善维持性血液透析患者营养状况及血脂的效果。方法:回顾性分析我院2009年12月至2012年12月间应用左卡尼汀治疗的48例维持性血液透析患者的临床资料。结果:所有患者应用左卡尼汀规律治疗12个月后,血清白蛋白水平升高(P<0.05),血红蛋白水平无明显改变(P>0.05),载脂蛋白A1水平下降(P<0.05)。结论:应用左卡尼汀能提高维持性血液透析患者血清白蛋白水平,改善患者营养状况。

Objective：To observe the effects of levocarnitine on nutritional status and blood lipid in hemodialysis patients.Methods：A retrospective study was performed on the clinical data of 48 hemodialysis patients,who received levocarnitine treatment from December 2009 to December 2012.Results：An increased serum albumin was observed in all of the 48 patients after 12-month levocarnitine-hemodialysis therapy（P ＜ 0.05）.The change of hemoglobin had no significant difference （P ＞ 0.05）.The hemo-Apo-A1 level was significantly lower after 12-month levocarnitine-hemodialysis therapy（P ＜ 0.05）.No significant changes were found in the other indicators after treatment.Conclusion：Levocarnitine therapy can improve the serum albumin levels in patients receiving hemodialysis and promote lipid metabolism.