2型糖尿病患者1,5-脱水葡萄糖醇与血脂的相关性分析

The correlation between 1,5-anhydroglucitol and blood lipid in type 2 diabetes mellitus

目的:探讨1,5-脱水葡萄糖醇(1,5-AG)与血脂存在的相互关系。方法:对312例2型糖尿病患者血脂、Hb Alc、1,5-AG水平进行分析,同时与同期183例健康对照组进行比较,并利用相关分析研究1,5-AG、Hb A1c与甘油三脂(TG)、总胆固醇(TC)等指标之间的相关性。结果:糖尿病患者TG、TC、Hb A1c明显高于健康对照组,而1,5-AG低于健康对照组(均为P<0.05)。Hb A1c与TC存在明显正相关性(P<0.05);而1,5-AG与TC存在良好的负相关性(P<0.01),与TG无明显相关性。结论:2型糖尿病患者存在明显的血脂异常,1,5-AG值越低,患者的TC水平越低。所以,临床治疗上不仅需重视血糖的控制,还需重视调脂治疗。

Objective：To explore the correlation between 1,5-anhydroglucitol （1,5-AG） and the presence of blood lipid in diabetic patients.Methods：In 312 cases of patients with type 2 diabetes,blood lipid,HbAlc and 1,5-AG levels were analyzed and compared to 183 cases of healthy people without hepar,renal,cardiovascular and cerebrovascular disease.Pearson analysis was also conducted to find any correlation amoung the levels of serum 1,5-AG,HbAlc and triglyceride（TG）,total cholesterol.Results：The levels of TG,TC,HbAlc in diabetic patients were significantly higher than those in healthy subjects,but the level of 1,5-AG was lower （all P ＜ 0.05）.Pearson correlation analysis showed that HbAlc was positively correlated to TC and serum 1,5-AG was highly negatively correlated with TC（P ＜ 0.01）,but was not significantly correlated with TG.Conclusion：There are significant dyslipidemia in patients with type 2 diabetes.The worse the glucose control,the higher the blood lipid spectrum.Therefore,in clinical treatment,we not only need to attach importance to blood glucose control,but also to the lipidlowering therapy.