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细胞胆固醇稳态失衡在非酒精性脂肪性肝病中的作用研究进展 被引量：2

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摘要 游离胆固醇(FC)的沉积可以直接损伤肝细胞,通过破坏线粒体和内质网(ER)膜的完整性,触发线粒体氧化损伤以及ER应激,同时促进有毒的羟胆固醇产生,直接诱导脂肪组织功能紊乱。肝细胞胆固醇稳态失衡,包括胆固醇内流增加、外流减少以及肠肝循环障碍都参与了非酒精性脂肪性肝病(NAFLD)的发病机制。通过药物来纠正胆固醇稳态失调将开启治疗NAFLD的新篇章。
作者 吴娱 马坤岭
机构地区 东南大学医学院 东南大学附属中大医院肾内科
出处 《东南大学学报（医学版）》 CAS 2014年第6期778-782,共5页 Journal of Southeast University(Medical Science Edition)
基金 国家自然科学基金资助项目(81070571 81170792) 江苏省普通高校研究生创新项目(CXZZ13-0132)
关键词 非酒精性脂肪性肝病 游离胆固醇 胆固醇稳态 文献综述
分类号 R575.5 [医药卫生—消化系统]
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参考文献40

  • 1MUSSO G, GAMBINO R,CASSADER M,et al. Meta-analysis: natural history of non- alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity[ J]. Ann Med ,2011,43 ( 8 ) :617-649.
  • 2TILG H, MOSCHEN A R. Evolution of inflammation in nonal- coholic fatty liver disease:the multiple parallel hits hypothesis [ J ]. Hepatology, 2010,52 ( 5 ) : 1836 - 1846.
  • 3NEUSCHWANDER-TETRI B A. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis:the central role of nontriglyceride fatty acid metabolites[ J]. Hepatology,2010,52 (2) :774-788.
  • 4TABAS I. Consequences of cellular cholesterol accumulation: basic concepts and physiological implications [ J]. J Clin Invest, 2002,110(7) :905-911.
  • 5MONTERO J, MARI M, COLELL A,et al. Cholesterol and per- oxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death [ J ]. Biochim Biophs Acta, 2010,1797(6) : 1217-1224.
  • 6MEI S, GU H, YANG X, et al. Prolonged exposure to insulin induces mitochondrion-derived oxidative stress through in- creasing mitochondrial cholesterol content in hepatocytes [ J ]. Endocrinology ,2012,153 (5) :2120-2129.
  • 7FU S, WATKINS S M, HOTAMISLIGIL G S. The role of endo- plasmic reticulum in hepatic lipid homeostasis and stress sig- nalin [ J ]. Cell Metab ,2012,15 (5) :623-634.
  • 8FERRI N, MARTNEZ- CLEMENTE M, LOPEZ- PARRA M, et al. Increased susceptibility to exacerbated liver injury in hyper- cholesterolemic ApoE-deficient mice:potential involvement of oxysterols [ J ]. Am J Physiol Gastrointest Liver Physiol, 2009, 296 ( 3 ) : G553- G562.
  • 9GARENC C ,JULIEN P,LEVY E. Oxysterols in biological sys- tems : the gastrointestinal tract, liver, vascular wall and central nervous system[J]. Free Radic Res,2009,44( 1 ) :47-73.
  • 10XU L, BAI Q, RODRIGUEZ-AGUDO D, et al. Regulation of hepatocyte lipid metabolism and inflammatory response by 25- hydroxycholesterol and 25- hydroxycholesterol- 3- sulfate [J]. Lipids,2010,45(9) :821-832.

二级参考文献18

  • 1SIMSEK S,SCHALKWIJK C G,WOLFFENBUTTEL B H. Effects of rosuvastatin and atorvastatin on glycaemic control in type 2 diabetes-the CORALL study[J].Diabetic Medicine,2011,(05):628-631.
  • 2TSUYOSHI N,ICHIRO M,ICHIRO M. Effects of ezetimibe on glucose metabolism in patients with type 2 diabetes:a 12-week,open-label,uncontrolled,pilotstudy[J].Current Therapeutic Research,2010,(04):252-258.
  • 3MICHIYO D,MITSUNORI N,AKIO K. Ezetimibe improves liversteatosis and insulin resistance in obese rat model of metabolic syndrome[J].FEBS Letters,2007,(29):5664-5670.
  • 4SUCHY D,LABUZEK K,STADNICKI A. Ezetimibe-a new approach in hypercholesterolemia management[J].PHARMACOLOGICAL REPORTS,2011,(06):1335-1348.
  • 5ALTMANN S W,DAVIS H R Jr,ZHU L J. NiemannPick C1 like 1 protein is critical for intestinal cholesterol absorption[J].SCIENCE,2004,(5661):1201-1204.
  • 6ZHONG Y,WANG J,GU P. Effect of Ezetimibe on Insulin Secretion in db/db[J].Exp Diabetes Res,2012.420854.
  • 7GOLDSTEIN B J,BITTNER K A,WHITE M F. Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B.Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein[J].Journal of Biological Chemistry,2000,(06):4283-4289.
  • 8KRAMER J,MOELLER E L,HACHEY A. Differential expression of GLUT2 in pancreatic islets and kidneys of New and Old World nonhuman primates[J].Am J Physiol Regul Integr Comp Physio1,2009,(03):R786-R793.
  • 9Ward S,Lloyd Jones M,Pandor A,et al.A systematic reviewand economic evaluation of statins for the prevention of coronary events[].Health Technology.2007
  • 10Ichihara S,Noda A,Nagata K,et al.Pravastatin increases sur-vival and suppresses anincrease in myocardial matrix metallopro-teinase activity in a rat model of heart failure[].Cardiovascular Research.2006

共引文献10

同被引文献35

  • 1郭继芬,胡蕾,徐赛,童玥.非酒精性脂肪肝炎的机制及治疗药物的研究进展[J].药物生物技术,2020(5):479-485. 被引量：10
  • 2乐玲娜,傅萍.非酒精性脂肪肝的中西医研究进展[J].世界最新医学信息文摘,2019,0(92):118-118. 被引量：9
  • 3马晓英,荆宇红,王建民,薛乐勋,蔡访勤.β－胡萝卜素抗氧化作用的实验研究[J].河南医学研究,1994,3(1):30-32. 被引量：1
  • 4CLARK J M, BRANCATI F L, DIEHL A M. Nonalcoholic fatty liver disease [ J 1. Gastroenterology, 2002,122 ( 6 ) : 1649-1657.
  • 5MONTO A. Hepatitis C and steatosis [ J ]. Semin Gastrointest Dis ,2002,13 ( 1 ) :40-46.
  • 6VERNON G,BARANOVA A,YOUNOSSI Z M. Systematic re- view:the epidemiology and natural history of non-alcoholic fat- ty liver disease and non-alcoholic steatohepatitis in adults[ J ]. Aliment Pharmacol Ther,2011,34 ( 3 ) :274-285.
  • 7TOBLLI J E, MUNOZ M C, CAO G,et al. ACE inhibition and AT1 receptor blockade prevent fatty liver and fibrosis in obese Zucker rats [ J ]. Obesity ( Silver Spring ), 2008, 16 ( 4 ) : 770-776.
  • 8RONG X,LI Y,EBIHARA K,et al. Angiotensin Ⅲ type 1 re- ceptor-independent beneficial effects of telmisartan on dietary- induced obesity,insulin resistance and fatty liver in mice[ J ]. Diabetologia,2010,53 ( 8 ) : 1727-1731.
  • 9MUNOZ M C,ARGENTINO D P,DOMINICI F P,et al. Irbe-sartan restores the in vivo insulin signaling pathway leading to Akt activation in obese Zucker rats [ J]. J Hypertens,2006,24 (8) :1607-1617.
  • 10MA K L,NI J,WANG C X,et al. Interaction of RAS activation and lipid disorders accelerates the progression of glomerulo- sclerosis[ J]. Int J Med Sci ,2013,10(12) : 1615-1624.

引证文献2

二级引证文献3

东南大学学报（医学版）
2014年 第6期

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