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microRNAs与肾脏纤维化 被引量：7

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摘要 肾脏纤维化是慢性肾脏病的共同病理特征,主要表现为细胞外基质的过度堆积和肾小管萎缩。MicroRNAs(miRNAs)是一类能在转录后水平调节大量基因的微小非编码RNA分子,miRNAs表达失调将导致细胞功能受损和疾病发生。作者综述了肾脏纤维化相关miRNAs的作用机制,着重阐述miR-192、miR-200家族、miR-29家族、miR-21的作用,以及相关miRNAs在肾脏纤维化中的靶向干预作用。
作者 汤涛涛 吕林莉 刘必成
机构地区 东南大学附属中大医院肾脏病研究所
出处 《东南大学学报（医学版）》 CAS 2014年第6期788-793,共6页 Journal of Southeast University(Medical Science Edition)
基金 国家自然科学基金重点项目(81130010) 江苏省自然科学基金资助项目(BK2011061) 国家973项目(2012CB517706)
关键词 MICRORNAS 慢性肾脏病 肾脏纤维化 文献综述
分类号 R692 [医药卫生—泌尿科学]
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参考文献38

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同被引文献40

  • 1Tampe D, Zeisberg M. Potential approaches to reverse or repair renal fibrosis[J]. Nat Rev Nephrol, 2014, 10(4) : 226 -237.
  • 2Duffield J S. Cellular and molecular mechanisms in kidney fibrosis [J]. J Clin Invest, 2014, 124(6) : 2299 -2306.
  • 3Martinez-Salgado C, Munoz-Felix J M, Perretta-Tejedor N. Regulation of renal fibrosis by the transforming growth factor beta-1 receptor Alk1 [J]. Biochim Biophys Acta, 2014, 1843(6): 1111-1122.
  • 4Sangkum P, Gokce A, Tan R B, et al. TGF-β1 induced urethral fibrosis in a rat model[J]. J Urol, 2015, 194(3) : 820 -827.
  • 5Wang B, Jha J C, Hagiwara S, et al. Transforming growth factor-β1- mediated renal fibrosis is dependent on the regulation of transforming growth faetor receptor 1 expression by let-7b[ J]. Kidney Int, 2014, 85(2) : 352 -361.
  • 6Di J, Jiang L, Zhou Y, et al. Ets-1 targeted by microRNA-221 regulates angiotensin II-induced renal fibroblast activation and fibrosis[J]. Cell Physiol Biochem, 2014, 34(4) : 1063 -1074.
  • 7Chen C H, Cheng C Y, Chen Y C, et al. microRNA-328 inhibits renal tubular cell epithelial-to-mesenchymal transition by targeting the CD44 in pressure-induced renal fibrosis [ J/OL ]. PLoS One, 2014, 9(6) : e99802, doi: 10. 1371/journal. pone. 0099802. eCollection 2014.
  • 8Jiang X, Yang L, Pang L, et al. Expression of obesity related miR-1908 in human adipocytes is regulated by adipokines, free fatty acids and hormones[J]. Mol Med Rep, 2014, 10(2): 1164-1169.
  • 9Yang L, Shi C M, Chen L, et al. The biological effects of hsa-miR-1908 in human adipocytes[J]. Mol Med Rep, 2015, 42(5) : 927 -935.
  • 10Ghanbari M, Sedaghat S, Looper H W, et al. The association of common polymorphisms in miR-196a2 with waist to hip ratio and miR-1908 with serum lipid and glucose [ J ]. Obesity, 2015, 23 (2) : 495 - 503.

引证文献7

二级引证文献24

东南大学学报（医学版）
2014年 第6期

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