壳聚糖季铵盐硅凝胶治疗增生性瘢痕的临床观察

Clinical observation of SQASC in the treatment of hypertrophic scar

目的:评价壳聚糖季铵盐硅凝胶治疗增生性瘢痕的临床疗效及不良反应。方法:选择200例增生性瘢痕患者,给予壳聚糖季铵盐硅凝胶和嘉氏堂自制的不含壳聚糖季铵盐的单纯硅凝胶进行治疗,观察1个疗程,通过对治疗前后的皮损颜色、皮损隆起的高度、皮损硬度、瘙痒、触痛这五个方面分别进行评分,综合评定其疗效及安全性。同时随访患者治疗结束后的副作用,随访至6个月。结果:壳聚糖季铵盐硅凝胶治疗增生性瘢痕有效率可达100%,单纯硅凝胶有效率为82%,均未发现任何毒副作用。结论:壳聚糖季铵盐硅凝胶治疗增生性瘢痕疗效显著,且安全无痛苦,值得临床推广应用。

Objective To evaluate the effect of SQASC in the treatment of hypertrophic scar and its untoward effect. Methods Chose 200 cases of hypertrophic scar patients, and observed the effect throughout one course of SQASC treatment and JiaShiTang＇s homemade pure silica gel, which didn＇t not contain quaternary ammonium salt of chitosan,Scores were based on these five aspects of the color of skin lesions, raised height of lesions,the hardness, itching and tenderness before and after the treatment. And assessed comprehensively curative effect and safety.Followed up patients for 6 months after the treatment in case of side effect. Results Its effectiveness for treating hyperplastic scar can reach 100%,and JiaShiTang＇s homemade pure silica gel,which didn＇t not contain quaternary ammonium salt of chitosan,can reach82% ,and have not found any side effects yet. Conlusion SQASC＇s therapeutic effect in the treatment of hypertrophic scar is significant,safe and painless,and so worthy of clinical application.