射频超声评价亚临床甲状腺功能减退症颈动脉弹性的临床价值

Evaluation of carotid artery elasticity in patients with subclinical hypothyroidism by ultrasound radi-frequency data technique

目的应用射频超声技术检测亚临床甲状腺功能减退症（SCH）患者颈动脉弹性功能。方法 SCH患者93例,据促甲状腺激素（TSH）水平分为SCH1组（TSH 4.2~10.0 m U/L）46例,SCH2组（TSH〉10.0 m U/L）47例,体检健康者50例为对照组。检测其血清总胆固醇、甘油三酯、低密度脂蛋白。射频超声检测其颈动脉弹性参数：内—中膜厚度（IMT）、顺应性系度（CC）、膨胀系数（DC）、弹性系数（α、β）、脉搏波速度（PWV）及动脉反射波增强指数（AIx）。结果 SCH2组总胆固醇、低密度脂蛋白高于对照组（P〈0.05）。与对照组相比,SCH1组DC、β、PWV、AIX均增高（P〈0.05）,SCH2组IMT、CC、DC、α、β、PWV、AIx均增高（P〈0.05）。SCH2组IMT、α、β、PWV、AIX高于SCH1组（P〈0.05）。DC与IMT、α、β、PWV呈负相关（P〈0.01）。CC与IMT、α、β、PWV呈负相关,与DC呈正相关（均P〈0.01）。AIX与IMT呈正相关,与DC呈负相关（均P〈0.01）。结论射频超声能尽早发现颈动脉弹性改变,为评估SCH患者大动脉损害提供重要的检测方法。

Objective To evaluate the carotid elasticity of patients with subclinical hypothyroidism using ultrasound radio-frequency （ RF） data technique. Methods Ninty-three patients with subclinical hypothyroidism were divided into SCH1 group（TSH4.2-10.0mU/L,46 patients）and SCH2 group（TSH〉10.0mU/L, 47 patients） and 50 health contrlos were enrolled. The TC, TG and LDL were examined in all subjects and the carotid elasticity parameters （IMT、CC、DC、α、β、PWV、Aix） were determined by ultrasound RF technique. Results The TC, LDL in SCH2 group were higher than those in the control group. Compared with the control group, the DC、β、PWV、AIX in SCH1 group and the IMT、CC、DC、α、β、PWV、AIx in SCH2 group were higher. The IMT、α、β、PWV、AIX in SCH2 group were higher compared with those in SCH1 group. DC was negatively correlated with IMT、α、βand PWV（P〈0.01）.CC was negatively correlated with IMT、α、β、PWV（P〈0.01）and positively correlated with DC （P〈0.01）.AIX was positively correlated with IMT （P〈0.01）,and negatively correlated with DC （P〈0.01）. Conclusion It can early detect the changes of carotid artery elasticity using ultrasound radio-frequency （RF） data technique, providing an important method for the evaluation of large artery damage in patients with subclinical hypothyroidism.